Lipids

PEG3-bis(Amino-Tri-(Propargyl-PEG2-ethoxymethyl)-methane) is a crosslinker consisting of six propargyl groups. The propargyl groups can form triazole linkage with azide-bearing compounds or biomolecules via copper catalyzed Click Chemistry. The hydrophilic PEG spacer increases solubility in aqueous media. Reagent grade, for research purpose.

14-(Bromoacetamido-PEG4-ethylcarbamoyl)tridecanoic-t-butyl ester has a bromine on a PEG linker with an alkane tail that has a t-butyl ester group. The bromine (Br) can be used as a leaving group for nucleophilic substitution reactions. The t-butyl group can be deprotected under acidic conditions. It is a self-assembling PEG reagent which may form micelles in water. This compound may also be used as a building block for lipids in nanotechnolgy and drug delivery. Reagent grade, for research purpose.

BP Lipid 229 is an amino ionizable lipid with an ethanolamine lipid head, enhancing encapsulation of mRNA. The lipid has primary esters at C8 position relative to the amine nitrogen. The lipid can be used for mRNA-based therapies which depends on the availability of a safe and efficient delivery vehicle. Reagent grade, for research purpose. Please contact us for GMP-grade inquiries.

BP Fluor 488 methyltetrazine is the BP Fluor 488 fluorophore and a methyltetrazine functional group, which is a click chemistry handle that rapidly ligates to trans-cyclooctene (TCO) groups on target molecules.

DSPE-PEG-TCO, MW 2,000 is a large PEG-lipid with a DSPE group and a trans-cyclooctyne moiety. DSPE is a phospholipid known for spontaneously forming micelles in aqueous media. DSPE-PEG conjugates are commonly used in the development of lipid nanoparticles in drug delivery. TCO is a click chemistry handle that is used with tetrazine-containing compounds for highly efficient labeling.

PEG3-bis(Amino-Tri-(Propargyl-PEG8-ethoxymethyl)-methane) is large molecule with two sets of three terminal alkynes joined together by a short PEG linker. The alkynes are most frequently used in copper click chemistry with azides to form stable triazoles with the target compound. The PEG linkers as well as numerous amide bonds provide high aqueous solubility to this compound, which may alter DMPK of this compound.

mPEG-DMG, MW 2,000 is a large PEG lipid containing a DMG group and a methoxy cap. The methoxy cap is inert while the DMG group is a popular component for developing lipid nanoparticles. Varying the size of a PEG linker greatly impacts its molecular dynamics, thereby affecting DMPK and ADME properties of a given API.

3-Amino-2-sulfopropanoic acid is a short molecule featuring a carboxylic acid, a sulfonate group, and a primary amine. The carboxylic acid and the primary amine are free to link this molecule to larger structures while the sulfonate group provides high water solubility to this aliphatic compound.

14-(Bromoacetamido-PEG6-ethylcarbamoyl)tridecanoic t-butyl ester is a bifunctional PEG linker containing a bromoacetamide, a PEG6 spacer, and a tridecanoic t-butyl ester. Bromoacetamide is a thiol-specific covalent ligand while the t-butyl ester can be hydrolyzed to allow for reactions with amines or alcohols to form amides or esters respectively.