Lipids

Lipid 2 is an ionizable aminolipid featuring a dimethylamine headgroup, a thiocarbamate linking to a central amine with two ester branches, one unsaturated C9 and a saturated C17. This compound may be employed in the development of lipid nanoparticles for drug delivery.

t-Boc-N-amido-PEG-Succinimidyl Carbonate, MW 5,000 is a PEG reagent containing a Boc-protected amine and a succinimidyl carbonate. The carbonate is a strong leaving group, being easily substituted by nucleophiles such as amines and alcohols to form new carbamates or carbonates respectively. The Boc group can be deprotected by acidic conditions, which frees the amine to react with functional groups such as carboxylic acids, aldehydes and ketones.

PEG3-bis(Amino-Tri-(Acid-ethoxymethyl)-methane) is a PEG linker containing two sets of three carboxylic acids joined together by a short PEG spacer. The carboxylic acids are open for reactions with nucleophiles such as amines to form amides with a target compound. The PEG linker provides aqueous solubility.

PEG13-bis(Amino-Tri-(Acid-ethoxymethyl)-methane) is a hexafunctional PEG linker containing a pair of three carboxylic acids joined together by a PEG spacer. The carboxylic acids are free for coupling reactions with amines and alcohols. The long PEG spacer provides high aqueous solubility and alters DMPK.

BP Lipid 309 is an ionizable lipid analogue of ALC-0315 featuring a tertiary amine head, a central tertiary amine, and two identical esters linking to nonpolar tails. Ionizable lipids such as this may be applied in the development of lipid nanoparticles for drug delivery. Reagent grade, for research purpose. Please contact us for GMP-grade inquiries.

D-Lin-MC2-DMA is a synthetic ionizable lipid that is frequently used in combination with other lipids in the development of lipid nanoparticles for drug delivery.

D-Lin-MC4-DMA is a synthetic ionizable lipid that is frequently used in combination with other lipids in the development of lipid nanoparticles for drug delivery.

BP Lipid 310 is an ionizable aminolipid analog of CL1. The structure features an ethanolamine head and an ester linking to a polyunsaturated hydrophobic tail. This lipid may be used to encapsulate nucleic acids or small-molecule drugs to form lipid nanoparticles for drug delivery. Reagent grade, for research purpose. Please contact us for GMP-grade inquiries.

DOPE-PEG-DBCO, MW 2,000 is a PEG-lipid containing a DOPE and a DBCO group. DOPE is a phospholipid that is commonly employed in the development of lipid nanoparticles. DBCO is a click chemistry handle which is used to react with azides and form stable triazoles with target molecules.