Lipids

Biotin-PEG4-Amide-PEG8-Amine is a PEG linker featuring a primary amine and a biotin group. Primary amines readily form amides with carboxylic acids in the presence of coupling reagents such as HATU or EDC. Biotin is used for affinity-based applications such as pull-down assays or for ligating with avidin proteins.

DSPE-Amide-PEG-Rhodamine, MW 2,000 is a PEG lipid with a DSPE group and a Rhodamine fluorophore. DSPE is a phospholipid that is known to spontaneously form micelles in water and is featured heavily in lipid nanoparticles and drug development. Rhodamine is a fluorescent dye with excitation and emission maxima at 570 and 595 nm respectively.

3-Hydroxy-2-(hydroxymethyl)propyl (9Z)-9-hexadecenoate is a lipid intermediate featuring a palmitoleate ester linked to a branched central carbon with two free primary alcohols. A compound like this may be employed in the development of lipid nanoparticles for drug delivery.

3-[4,4-Bis(octyloxy)-1-oxobutoxy]-2-(hydroxymethyl)propyl (9Z)-9-hexadecenoate is a lipid molecule featuring a primary alcohol, a palmitoleic acid, and a butanoic acid linked to two C8 chains via an acetal. Compounds such as this may also be used as intermediates in building lipids for use in lipid nanoparticles.

BP Lipid 313 is an ionizable lipid analogue of ALC-0315 featuring an ethanolamine head and two carbamate tails, one being an undecyl tail and the other being a branched C17. Ionizable lipids such as this may be applied in the development of lipid nanoparticles for drug delivery. Reagent grade, for research purpose. Please contact us for GMP-grade inquiries.

t-Boc-N-amido-PEG4-Val-Cit is a protease-cleavable ADC linker featuring a Boc-protected amine, a hydrophilic PEG spacer, and a Val-Cit dipeptide. The Val-Cit dipeptide is cleavable by cell proteases and features a carboxylic acid which is free for coupling reactions with amines to form amides. The Boc can be removed under acidic conditions to reveal a free primary amine, which may be used in a variety of reactions such as coupling or reductive amination.

This reagent is a modified lipid containing an omega-terminal alkyne. The terminal alkyne group can be used in a highly specific linking reaction with azide-containing reagents, known as click chemistry, in the presence of a copper (Cu)-containing catalyst. Alkyne cholesterol represents a versatile, sensitive, and easy-to-use tool for tracking cellular cholesterol metabolism and localization as it allows for manifold detection methods including mass spectrometry, and fluorescence microscopy.

This reagent is a modified lipid containing an omega-terminal alkyne. The terminal alkyne group can be used in a highly specific linking reaction with azide-containing reagents, known as click chemistry, in the presence of a copper-containing catalyst. Alkyne cholesterol represents a versatile, sensitive, and easy-to-use tool for tracking cellular cholesterol metabolism and localization as it allows for manifold detection methods including mass spectrometry, and fluorescence microscopy.

This reagent is a modified lipid containing an omega-terminal alkyne. The terminal alkyne group can be used in a highly specific linking reaction with azide-containing reagents, known as click chemistry, in the presence of a copper (Cu)-containing catalyst. E-Cholesterol Alkyne (19-ethynylcholesterol) represents a versatile, sensitive, and easy-to-use tool for tracking cellular cholesterol metabolism and localization as it allows for manifold detection methods including mass spectrometry, and fluorescence microscopy.