Lipids

Boc-Gly-Gly-Gly-PEG-methyltetrazine is a PEG linker featuring a methyltetrazine and a glycine tripeptide featuring a Boc-protected N-terminus. Methyltetrazine is a click chemistry handles that can react with TCO groups while the Boc protecting group can be removed to reveal a primary amine.

Mal-amide-PEG8-Val-Cit-PAB-PNP is a cleavable ADC linker featuring a maleimide, a PEG spacer, a Val-Cit dipeptide, a PAB. and a PNP carbonate. Maleimide is a thiol-specific covalent linker which is used to label cysteine residues in proteins while the PNP group acts as a highly activated leaving group. Val-Cit linkers are cleaved by cytoplasmic peptidases.

BP Lipid 323 is an ionizable aminolipid analog of CL1 which features a unique azetidine head and an ester linking to a polyunsaturated hydrophobic tail. Ionizable lipids such as this may be applied in the development of lipid nanoparticles for drug delivery. Reagent grade, for research purpose. Please contact us for GMP-grade inquiries.

Fmoc-PEG8-bromide is a bifunctional PEG linker featuring an Fmoc-protected primary amine and a bromide. The bromide is a good leaving group which is displaced by nucleophiles while the Fmoc protecting group can be removed to reveal a primary amine.

BP Lipid 316 is an ionizable lipid analogue of DLin-MC3-DMA featuring a 4-(dimethylamino)butanoate head, two linoleic acid tails, and one primary alcohol. The alcohol may be used to further derivatize this compound. Ionizable lipids such as this may be applied in the development of lipid nanoparticles for drug delivery. Reagent grade, for research purpose. Please contact us for GMP-grade inquiries.

3-Arm PEG4-Azide is a homotrifunctional PEG linker containing three azides, which can be used in click chemistry with terminal alkynes and strained cyclooctynes like DBCO and BCN. The use of PEG linkers over their alkane counterparts provides high aqueous solubility and alters in vivo pharmacodynamics.

DOPE-PEG-Cy5.5, MW 2,000 is a PEG-lipid-dye conjugate featuring a DOPE phospholipid and a Cy5.5 dye. DOPE is featured prominently in lipid nanoparticles for its ability to readily form micelles while Cy5.5 is a fluorescent dye which is used in histology, FRET and other fluorescence-based assays in vivo.

ZXH 3-26 degrades BRD4 while not exhibiting any significant degradation of BRD2 or BRD3. This product is ready for conjugation to target proteins for PROTAC R&D. Reagent grade, for research purpose. Please contact us for GMP-grade inquiries.

3,4-(PEG4-Azide)-2-((PEG4-Azide)methyl)propan-1-ol is a multifunctional reagent combining three azides and a primary alcohol. The azide group is commonly used in click chemistry for reactions with terminal alkynes as well as strained cyclooctynes such as BCN or DBCO. The primary alcohol is a useful scaffold for building molecular complexity such as for creating esters or substitution with any number of functional groups. The use of a PEG linker increases this compound’s aqueous solubility, altering its DMPK properties in drug development.