Lipids

Phosphatidylethanol (16:0 LysoPEth) is formed primarily in the liver by transphosphatidylation of phosphatidylcholine (PC) by phospholipase D in the presence of ethanol. PEth is a long-lived circulating ethanol biomarker with forensic and biomedical applications. LysoPEth is formed either through loss of the sn-1 acyl chain or transphosphatidylation of LysoPC. It is also reported to be a biomarker of alcohol consumption.

Lipid A monophosphoryl from Salmonella minnesota R595

DOG-IM4 is an ionizable lipid which is used to deliver mRNA by forming lipid nanoparticles (LNPs). DOG-IM4 can improve the thermostability of mRNA/LNP in combination with helper lipids.

Lipid CP-LC-0741 is an ionizable cationic amino lipid derived from homocysteine, a naturally occurring amino acid. This lipid has demonstrated an efficient delivery and high protein expression of different kinds of RNA (mRNA, cRNA and saRNA) in vivo, with no signs of toxicity.

Lipid CP-LC-1073 is an ionizable cationic amino lipid derived from homocysteine, a naturally occurring amino acid. This lipid has demonstrated an efficient delivery and high protein expression of different kinds of RNA (mRNA, cRNA and saRNA) in vivo. Moreover, using a typical LNP formulation (IL/Ch/DOPE/PEG: 50/38.5/10/1.5), it has shown to induce specific lung targeting much more efficiently that other commercial alternatives through IV injection, with no signs of toxicity.

Lipid CP-LC-1405 is an ionizable cationic amino lipid derived from homocysteine, a naturally occurring amino acid. This lipid has demonstrated an efficient delivery and high protein expression of different kinds of RNA (mRNA, cRNA and saRNA) in vivo, with no signs of toxicity.

Lipid CP-LC-1406 is an ionizable cationic amino lipid derived from homocysteine, a naturally occurring amino acid. This lipid has demonstrated an efficient delivery and high protein expression of different kinds of RNA (mRNA, cRNA and saRNA) in vivo, with no signs of toxicity.

Lipid CP-LC-1447 is an ionizable cationic amino lipid derived from homocysteine, a naturally occurring amino acid. This lipid has demonstrated an efficient delivery and high protein expression of different kinds of RNA (mRNA, cRNA and saRNA) in vivo. Moreover, using a typical LNP formulation (IL/Ch/DOPE/PEG: 50/38.5/10/1.5), it has shown to induce specific spleen targeting much more efficiently that other commercial alternatives through IV injection, with no signs of toxicity.

Propargyl-PEG-acid, MW 2,000 constitutes a polyPEG linker with a 2k PEG polymer for enhanced hydrophilicity and propargyl group that can participate in copper catalyzed azide-alkyne Click Chemistry. Reagent grade, for research purpose. Please contact us for GMP-grade inquiries.