Lipids

Lipid 14 is an ionizable amino lipid used in creating lipid nanoparticles (LNPs). These LNPs encapsulate mRNA encoding the severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) spike glycoprotein receptor-binding domain (RBD), enhancing anti-RBD antibody levels in mice.

OF-Deg-Lin is an ionizable lipid employed in creating lipid nanoparticles (LNPs) for in vitro mRNA delivery.

DOG-IM4 may be incorporated into lipid nanoparticles (LNPs) containing mRNA for influenza A hemagglutinin (HA). Immunization with these LNPs leads to increased HA-inhibiting antibody titers in both mice and cynomolgus macaques.

246C10 is an ionizable lipid with a multi chargeable piperazine, and it is used in creating lipid nanoparticles (LNPs) for in vitro and in vivo mRNA delivery. These LNPs, containing an encapsulated mRNA reporter, selectively accumulate in the mouse liver.

IC8 is an ionizable lipid with a multi chargeable piperazine linked to two branched, tertiary amines. Immunization with SARS-CoV-2 spike glycoprotein mRNA in IC8- and manganese-containing LNPs induces IgG responses to both SARS-CoV-2 Delta and Omicron variants in mice.

AA-T3A-C12 is an ionizable lipidoid with a polyamine core, linked to the sigma receptor ligand anisamide, and features four 12-carbon tails. It has been utilized in creating lipid nanoparticles (LNPs). These LNPs, encapsulating siRNA for Hsp47, effectively reduce Hsp47 expression in activated NIH3T3 mouse liver fibroblasts and primary mouse hepatic stellate cells, which is crucial in addressing liver fibrosis.

IAJD93 (pKa = 6.25) is a specialized ionizable lipid dendrimer that effectively transports mRNA.

IAJD249 (pKa of 6.35) represents a significant advancement in mRNA delivery. When combined with mRNA, it spontaneously assembles into dendrimersome nanoparticles (DNPs) within an acetate buffer.

ALC-0315 N-oxide is identified as an impurity present in commercially available ALC-0315, an ionizable lipid used in the formulation of LNP-mRNA.