Lipids

A triacylglyceride analog featuring two 15-methyl palmitic acid tails and one unsaturaed linoleic acid tail. Introduction of the iso- methyl branched fatty acids has been carefully desgined to investigate the effect on self-assembly properties, solubilization of other lipids, and membrane fluidity. Reagent grade, for research purpose. Please contact us for GMP-grade.

PC Mal-PEG4-NHS carbonate ester represents a photocleavable linker with a terminal maleimide that can react with thiol or cysteine to generate a thiosuccinimide molecule which is commonly used for bioconjugation. NHS carbonate ester labels the primary amines (-NH2) of proteins, amine-modified oligonucleotides, and other amine-containing molecules. The PEG spacer imparts hydrophilicity. This structure allows for efficient photorelease of linked molecules, typically achieving over 90% cleavage in 5-25 minutes using a near-UV lamp.

BP Lipid 437 is a branched multichargeable lipid featuring a piperazine core with amide linkage to asymmetric aliphatic tails. This compound may be used in the formulation of lipid nanoparticles (LNP's) for mRNA delivery applications. Reagent grade, for research purpose. Please contact us for GMP-grade inquiries.

BP Lipid 438 is a mutichargeable lipid featuring a piperazine core, symmetric aliphatic amine spacers, and amide linkages to two fatty tails. This compound may be used in the formulation of lipid nanoparticles (LNP's) for mRNA or drug delivery applications. Reagent grade, for research purpose. Please contact us for GMP-grade inquiries.

DBCO-PEG12-PFP ester consists of a DBCO which can be used for copper-free Click Chemistry reactions and PFP, which acts as a good leaving group that is readily displaced by amines to form amides. The PEG12 units improve the water solubility of the compound.

DSDMA is a fully saturated ionizable ether lipid featuring a dimethylamino head group and stearyl aliphatic tails. This compound may be used in the formulation of lipid nanoparticles (LNP's) for mRNA delivery applications. Reagent grade, for research purpose. Please contact us for GMP-grade inquiries.

DSPE-PEG-Hz-mal, MW 2,000 is a polyPEG compound with DSPE and maleimide groups. The DSPE-PEGs have been FDA approved for medical applications. The hydrophobic properties of the DSPE allow for the encapsulation and congregation of other hydrophobic drugs. The hydrophilic polyPEG increases the water solubility of the overall compound allowing for the delivery of the drug. Maleimide groups can react with thiol groups between pH 6.5 to 7.5.

An aliphatic amine featuring two oleyl fatty acid tails and a polar ethanolamine head group. This useful lipid scaffold may be further functionalized at the reactive free hydroxyl or used as a functional component for lipid nanoparticles. Reagent grade, for research purpose. Please contact us for GMP-grade.

An aliphatic amine featuring two saturated stearyl aliphatic tails and a polar ethanolamine head group. This useful lipid scaffold may be further functionalized at the reactive free hydroxyl or used as a functional component for solid lipid nanoparticles for drug delivery. Reagent grade, for research purpose. Please contact us for GMP-grade.