Lipids

(BODIPY FL Phosphatidylinositol 3 4-bisphosphate) is a water soluble analog of PI(3 4)P2 labeled with the green fluorophore Bodipy®-FL at the sn-1 position.Phosphoinositides (PIPns) are minor components of cellular membranes but are integral signaling molecules for cellular communication. Phosphatidylinositol 3 4-bisphosphate (PI(3 4)P2) is produced in stimulated cells by the action of phosphatidylinositol 3-kinases (PI3Ks) and/or lipid phosphatases (SHIP TPTE etc.). PI(3 4)P2 binds the pleckstrin homology (PH)-domain of AKT/PKB leading to cell survival and it also has an important role in podosome formation near focal adhesions.Bulk discounts available please email echelon@echelon-inc.com for information.

BODIPY TMR Phosphatidylinositol 3 4-bisphosphate is a water soluble analog of PI(3 4)P2 labeled with the orange fluorophore Bodipy®-TMR at the sn-1 position.Phosphoinositides (PIPns) are minor components of cellular membranes but are integral signaling molecules for cellular communication. Phosphatidylinositol 3 4-bisphosphate (PI(3 4)P2) is produced in stimulated cells by the action of phosphatidylinositol 3-kinases (PI3Ks) and/or lipid phosphatases (SHIP TPTE etc.). PI(3 4)P2 binds the pleckstrin homology (PH)-domain of AKT/PKB leading to cell survival and it also has an important role in podosome formation near focal adhesions.Bulk discounts available please email echelon@echelon-inc.com for information.

Phosphoinositides (PIPns) are minor components of cellular membranes but are integral signaling molecules for cellular communication. Phosphatidylinositol 3 4-bisphosphate (PI(3 4)P2) is produced in stimulated cells by the action of phosphatidylinositol 3-kinases (PI3Ks) and/or lipid phosphatases (SHIP TPTE etc.). PI(3 4)P2 binds the pleckstrin homology (PH)-domain of AKT/PKB leading to cell survival and it also has an important role in podosome formation near focal adhesions.GloPIPs are labeled at the sn-1 position with BODIPY®-FL (505/513) BODIPY®-TMR (544/574) or biotin. The sn-1 linkage in these labeled PIPs has been changed to a more stable amide from an ester. Results from experiments conducted at Echelon indicated that this minor chemical change did not have a significant effect in any of the applications tested.Bulk discounts available please email echelon@echelon-inc.com for information.

Biotin Phosphatidylinositol 3 5-bisphosphate is a water soluble analog of PI(3 5)P2 labeled with biotin at the sn-1 position.Phosphoinositides (PIPns) are minor components of cellular membranes but are integral signaling molecules for cellular communication. Phosphatidylinositol 3 5-bisphosphate is in very low abundance and is required for retrograde membrane trafficking from lysosomal and late endosomal compartments to the Golgi and is involved in autophagy. PI(3 5)P2 levels are controlled by the 5-kinase PIKfyve and the 5-phosphatase Fig4/Sac3 and disregulation is linked to several human neuropathies (eg Chacot-Marie-Tooth disease). Bulk discounts available please email echelon@echelon-inc.com for information.

Phosphoinositides (PIPns) are minor components of cellular membranes but are integral signaling molecules for cellular communication. Phosphatidylinositol 3 5-bisphosphate is in very low abundance and is required for retrograde membrane trafficking from lysosomal and late endosomal compartments to the Golgi and is involved in autophagy. PI(3 5)P2 levels are controlled by the 5-kinase PIKfyve and the 5-phosphatase Fig4/Sac3 and disregulation is linked to several human neuropathies (eg Chacot-Marie-Tooth disease).GloPIPs are labeled at the sn-1 position with BODIPY®-FL (505/513) BODIPY®-TMR (544/574) or biotin. The sn-1 linkage in these labeled PIPs has been changed to a more stable amide from an ester. Results from experiments conducted at Echelon indicated that this minor chemical change did not have a significant effect in any of the applications tested.Bulk discounts available please email echelon@echelon-inc.com for information.Publications Powered by Bioz See more details on

BODIPY FL PI(3 5)P2 (BODIPY FL Phosphatidylinositol 3 5-bisphosphate) is a water soluble analog of PI(3 5)P2 labeled with the green fluorophore Bodipy®-FL at the sn-1 position.Phosphoinositides (PIPns) are minor components of cellular membranes but are integral signaling molecules for cellular communication. Phosphatidylinositol 3 5-bisphosphate is in very low abundance and is required for retrograde membrane trafficking from lysosomal and late endosomal compartments to the Golgi and is involved in autophagy. PI(3 5)P2 levels are controlled by the 5-kinase PIKfyve and the 5-phosphatase Fig4/Sac3 and disregulation is linked to several human neuropathies (eg Chacot-Marie-Tooth disease).Bulk discounts available please email echelon@echelon-inc.com for information.

Phosphoinositides (PIPns) are minor components of cellular membranes but are integral signaling molecules for cellular communication. Phosphatidylinositol 3 5-bisphosphate is in very low abundance and is required for retrograde membrane trafficking from lysosomal and late endosomal compartments to the Golgi and is involved in autophagy. PI(3 5)P2 levels are controlled by the 5-kinase PIKfyve and the 5-phosphatase Fig4/Sac3 and disregulation is linked to several human neuropathies (eg Chacot-Marie-Tooth disease).GloPIPs are labeled at the sn-1 position with BODIPY®-FL (505/513) BODIPY®-TMR (544/574) or biotin. The sn-1 linkage in these labeled PIPs has been changed to a more stable amide from an ester. Results from experiments conducted at Echelon indicated that this minor chemical change did not have a significant effect in any of the applications tested.Bulk discounts available please email echelon@echelon-inc.com for information.

BODIPY TMR PI(3 5)P2 (BODIPY TMR Phosphatidylinositol 3 5-bisphosphate) is a water soluble analog of PI(3 5)P2 labeled with the orange fluorophore Bodipy®-TMR at the sn-1 position.Phosphoinositides (PIPns) are minor components of cellular membranes but are integral signaling molecules for cellular communication. Phosphatidylinositol 3 5-bisphosphate is in very low abundance and is required for retrograde membrane trafficking from lysosomal and late endosomal compartments to the Golgi and is involved in autophagy. PI(3 5)P2 levels are controlled by the 5-kinase PIKfyve and the 5-phosphatase Fig4/Sac3 and disregulation is linked to several human neuropathies (eg Chacot-Marie-Tooth disease).Bulk discounts available please email echelon@echelon-inc.com for information.

Biotin PI(3 4 5)P3 (Biotin Phosphatidylinositol 3 4 5-trisphosphate) is a water soluble analog of PI(3 4 5)P2 (PIP3) labeled with biotin at the sn-1 position.Phosphoinositides (PIPns) are minor components of cellular membranes but are integral signaling molecules for cellular communication. Phosphatidylinositol 3 4 5-trisphosphate (PIP3) formed from PI(4 5)P2 though phosphorylation by PI 3-kinase activates numerous signaling pathways resulting in cell proliferation growth survival glucose transport and protein synthesis. High PIP3 levels from disregulation of PI3-K have been demonstrated in cancer and inflammatory diseases. PIP3 is hydrolyzed by the phosphatases PTEN to PI(4 5)P2 and SHIP to PI(3 4)P2.Featured in Publications1. Anzelon A. N. H. Wu et al. (2003). "Pten inactivation alters peripheral B lymphocyte fate and reconstitutes CD19 function." Nat Immunol 4(3): 287-94.2. Bidlingmaier S. et al. (2011). "Comprehensive analysis of yeast surface displayed cDNA library selec