Lipids

1-Stearoyl-2-arachidonoyl-sn-glycerol is a diacylglycerol (DAG) with polyunsaturated fatty acid arachidonic acid and stearic acid in the sn-1 and sn-2 positions respectively. 1-Stearoyl-2-arachidonoyl-sn-glycerol is a diacylglycerol is a potent activator of PKCα PKCε and PKCδ and also competitively binds to the Ras activator RasGRP. 1 2-Diacylglycerols are formed in cells through the hydrolysis of phosphatidylinositol 4 5-bisphosphate by Phospholipase C. DAGs activate Protein Kinase C (PKC) which is a key regulator of signal transduction cellular regulation and tumor promotion.References1) Lapetina E.G. Reep B. Ganong B.R. & Bell R.M. (1985) "Exogenous sn-1 2-diacylglycerols Containing Saturated Fatty Acids Functions as Bioregulators of Protein Kinase C in Human Platelets" J. Biol. Chem. 260 1358-1361.2) Ganong B.R. Loomis C.R. Hannun Y.A. & Bell R.M. (1986) "Specificity and Mechanism of Protein Kinase C Activation by sn-1 2-diacylglycerols" Proc. Na

Nitrooleic acid (OA-NO2) is formed by nitration of oleic acid from excessive nitric oxide during inflammation (nitrative stress). OA-NO2 is a potent signaling molecule which can activate numerous receptors including TRPA1 cation channels and PPARγ. 9(10)-Nitrooleic acid is a mixture of the 9-nitro and 10-nitro isomers which are formed in equal amounts in vivo.References1. P.S. Baker et al “Fatty Acid Transduction of Nitric Oxide signaling” Journal of Biological Chemistry 2005 280 42464-42475;2. F.J. Schopfer et al “Covalent Peroxisome Proliferator-Activated Receptor Adduction By Nitro-Fatty Acid” Journal of Biological Chemistry 2010 285 12321-12333.

Lysophosphatidic Acid (LPA) is a small lysophospholipid involved in diverse cellular processes such as cell proliferation chemotaxis platelet aggregation wound healing angiogenesis tumor invasion and smooth muscle contraction. LPA binds to several G-coupled protein receptors to initiate its biological functions. In cancer LPA primarily promotes cell survival migration and invasion. LPA Biotin is labeled at the sn-1 position.

Oleoyl LPA 18:1 LPA is a species of lysophosphatidic acid containing oleic acid at the sn-1 position and is the most potent LPA analog for calcium release. Lysophosphatidic Acid (LPA) is a small lysophospholipid involved in diverse cellular processes such as cell proliferation chemotaxis platelet aggregation wound healing angiogenesis tumor invasion and smooth muscle contraction. LPA binds to several G-coupled protein receptors to initiate its biological functions. In cancer LPA primarily promotes cell survival migration and invasion. May contain up to 15% of the 2-acyl isomer due to acyl transfer.

Linoleoyl LPA 18:2 LPA is an LPA analog with an unsaturated acyl chain. Lysophosphatidic Acid (LPA) is a small lysophospholipid involved in diverse cellular processes such as cell proliferation chemotaxis platelet aggregation wound healing angiogenesis tumor invasion and smooth muscle contraction. LPA binds to several G-coupled protein receptors to initiate its biological functions. In cancer LPA primarily promotes cell survival migration and invasion. May contain up to 15% of the 2-acyl isomer due to acyl transfer.

Linoleoyl LPA-d5 is a deuterated analog of 18:2-LPA that can be used as a standard in mass spectrometry and lipidomics. Lysophosphatidic Acid (LPA) is a small lysophospholipid involved in diverse cellular processes such as cell proliferation chemotaxis platelet aggregation wound healing angiogenesis tumor invasion and smooth muscle contraction.  LPA binds to several G-coupled protein receptors to initiate its biological functions. In cancer LPA primarily promotes cell survival migration and invasion. May contain up to 15% of the 2-acyl isomer due to acyl transfer.

Linolenoyl LPA 18:3 is an LPA analog with an unsaturated acyl chain. Lysophosphatidic Acid (LPA) is a small lysophospholipid involved in diverse cellular processes such as cell proliferation chemotaxis platelet aggregation wound healing angiogenesis tumor invasion and smooth muscle contraction. LPA binds to several G-coupled protein receptors to initiate its biological functions. In cancer LPA primarily promotes cell survival migration and invasion. May contain up to 15% of the 2-acyl isomer due to acyl transfer.

(2S)-Oleyl LPA is an analog of 18:1 LPA in which the fatty ester bond to gycerol has been replaced by a metabolically stable ether linkage. Lysophosphatidic Acid (LPA) is a small lysophospholipid involved in diverse cellular processes such as cell proliferation chemotaxis platelet aggregation wound healing angiogenesis tumor invasion and smooth muscle contraction. LPA binds to several G-coupled protein receptors to initiate its biological functions. In cancer LPA primarily promotes cell survival migration and invasion.

Arachidoyl LPA 20:0 LPA (aka Eicosanoyl LPA) is an analog of lysophosphatidic acid (LPA) a lysophospholipid involved in cell proliferation. Lysophosphatidic Acid (LPA) is a small lysophospholipid involved in diverse cellular processes such as cell proliferation chemotaxis platelet aggregation wound healing angiogenesis tumor invasion and smooth muscle contraction. LPA binds to several G-coupled protein receptors to initiate its biological functions. In cancer LPA primarily promotes cell survival migration and invasion. May contain up to 15% of the 2-acyl isomer due to acyl transfer.