Lipids

1-Palmitoyl-2-linoleoyl-sn-glycero-3-phosphocholine (PLPC) is a phosphocholine with palmitic (16:0) and linoleic (18:2) acids acyl chains.Phosphatidylcholine (PC) is generally the most abundant lipid in animal cell membranes providing structural framework. PC is more common in the outer leaflet where it functions as part of the permeability barrier. PC is also the primary substrate of Phospholipase D enzymes which produce the signaling lipids - phosphatidic acid and lysophosphatidic acid.

XY-4 ((R)-1 1-difluoro-3-(phosphonooxy)propan-2-yl palmitate) is an analog of 2-palmitoyl lysophosphatidic acid (LPA) in which the sn-1 hydroxyl has been replaced by two fluorines. It acts as a selective agonist of peroxisome proliferator-activated receptor γ (PPARγ) but does not stimulate LPA1 LPA2 or LPA3 receptors. PPARγ is a transcription factor of the nuclear receptor superfamily and has been implicated in atherogenesis.

1 2-Dioleoyl-sn-glycero-3-phosphocholine (DOPC) is a phosphatidylcholine (36:2) in which the phosphatidyl acyl groups at positions 1 and 2 are both oleoyl.Phosphatidylcholine (PC) is generally the most abundant lipid in animal cell membranes providing structural framework. PC is more common in the outer leaflet where it functions as part of the permeability barrier. PC is also the primary substrate of Phospholipase D enzymes which produce the signaling lipids - phosphatidic acid and lysophosphatidic acid. Powered by Bioz See more details on Bioz

Biotin-Phosphatidylcholine is a functionalized phosphatidylcholine with biotin conjugated to the sn1 acyl chain.Phosphatidylcholine (PC) is generally the most abundant lipid in animal cell membranes providing structural framework. PC is more common in the outer leaflet where it functions as part of the permeability barrier. PC is also the primary substrate of Phospholipase D enzymes which produce the signaling lipids - phosphatidic acid and lysophosphatidic acid.

Miltefosine is effective against visceral infections of Leishmanis species through inhibiton of cytochrome c oxidase. In addition Miltefosine inhibits CTP:phosphocholine cytidylyltransferase and has anti-metastatic effects.References1) Rivas L. & Luque-Ortega J.R. “Miltefosine (hexadecylphosphocholine) inhibits cytochrome c oxidase in Leishmania donovani promastigotes.” (2007) Antimicrob. Chemother. Agents 51 1327-1332.2) Geilen C.C. Wieder T. Reutter W. “Hexadecylphosphocholine inhibits translocation of CTP: Choline-phosphate cytidylyltransferase in Madin-Darby canine kidney cells.” (1992). J Biol Chem. 267 6719-6724.

1-Palmitoyl-2-hydroxy-sn-glycero-3-phosphocholine (P-lysoPC LPC) is generated through hydrolysis of the sn-2 acyl chain of PC by phospholipase A2. It is a major component of oxidized low-density lipoprotein and is believed to have an important role in inflammatory diseases and atherosclerosis. LysoPC is the substrate for Autotaxin/LysoPLD generating lysophosphatidic acid which has an important role in cell motility.

1-Stearoyl-2-hydroxy-sn-glycero-3-phosphocholine (S-lysoPC LPC) is generated through hydrolysis of the sn-2 acyl chain of PC by phospholipase A2. It is a major component of oxidized low-density lipoprotein and is believed to have an important role in inflammatory diseases and atherosclerosis. LysoPC is the substrate for Autotaxin/LysoPLD generating lysophosphatidic acid which has an important role in cell motility.

1-Linoleoyl-2-hydroxy-sn-glycero-3-phosphocholine (18:2 lyso-PC) is generated through hydrolysis of the sn-2 acyl chain of PC by phospholipase A2. It is a major component of oxidized low-density lipoprotein and is believed to have an important role in inflammatory diseases and atherosclerosis. LysoPC is the substrate for Autotaxin/LysoPLD generating lysophosphatidic acid which has an important role in cell motility.The product contains up to 10-15% of the 2-acyl isomer.

LysoPC is generated through hydrolysis of the sn-2 acyl chain of PC by phospholipase A2. It is a major component of oxidized low-density lipoprotein and is believed to have an important role in inflammatory diseases and atherosclerosis. LysoPC is the substrate for Autotaxin/LysoPLD generating lysophosphatidic acid which has an important role in cell motility. The biotin 18:0 LysoPC analog is biotinylated at the end of the sn-1 acyl chain and can be used for binding to streptavidin-coated surfaces such as beads plates etc.ReferencesMatsumoto T. Kobayashi T. Kamata K. (2007) Role of lysophosphatidylcholine (LPC) in atherosclerosis. Curr. Med. Chem. 14 3209-3220