PEG

N-(Hydroxy-PEG3)-N-bis(PEG4-t-butyl ester) is a branched PEG linker with a terminal hydroxy group and two t-butyl esters. The hydroxy group enables further derivatization or replacement with other reactive functional groups. The t-butyl protected carboxyl groups can be deprotected under mild acidic conditions. Reagent grade, for research purpose. Please contact us for GMP-grade inquiries.

N-(Boc-PEG4)-NH-PEG4-t-butyl ester is a small molecule intermediate containing an amino group, a t-butyl ester and Boc protected amino group. The amino group can react with carboxylic acids, activated NHS esters, and carbonyls. The protected amine can be deprotected under acidic conditions. Reagent grade, for research purpose. Please contact us for GMP-grade inquiries.

Tos-PEG4-methyl ester is a PEG linker with tosyl and methyl ester moieties. The tosyl group is a very good leaving group for nucleophilic substitution reactions. The hydrophilic PEG linker increases the water solubility of the compound. Methyl ester can be hydrolyzed under strong basic condition. Reagent grade, for research purpose. Please contact us for GMP-grade inquiries.

N-(Aminooxy-PEG3)-N-bis(PEG4-t-butyl ester) is a branched aminooxy linker. It can react with aldehyde to form an oxime bond. If a reductant is used, it will form a hydroxylamine linkage. The t-butyl ester group can be hydrolyzed under acidic conditions. The hydrophilic PEG linkers increase the water solubility of the compound. Reagent grade, for research purpose. Please contact us for GMP-grade inquiries. Aminooxy compounds are very reactive and sensitive; they cannot be stored for long term. Immediate use (within 1 week) is highly recommended.

N-(Azido-PEG4)-N-Boc-PEG4-t-butyl ester is reactive with alkyne such as BCN, DBCO…through Click Chemistry. Boc and the t-butyl ester group can be deprotected under mild acidic conditions. Reagent grade, for research purpose. Please contact us for GMP-grade inquiries.

t-Butyl 3-(hydroxypropoxyl)-propanoate contains reactive hydroxyl and t-butyl protected carboxyl moieties. The hydroxyl group can react to further derivatize the compound. The t-butyl carbonyl group can be deprotected under acidic conditions. Reagent grade, for research purpose. Please contact us for GMP-grade inquiries.

Propargyl-PEG10-amine is a PEG reagent that is reactive with carboxylic acids, activated NHS esters, carbonyls (ketone, aldehyde) etc. The propargyl group enables Click Chemistry reactions with azide-bearing compounds or biomolecules; copper catalyst is required. Reagent grade, for research purpose. Please contact us for GMP-grade inquiries.

N-(t-Boc-Aminooxy-PEG2)-N-bis(PEG3-propargyl) is a branched crosslinker molecule with two terminal propargyl groups and a t-Boc protected aminooxy group. The propargyl groups can react with azide-bearing compounds or biomolecules via copper catalyzed azide-alkyne Click Chemistry to yield a stable triazole linkage. The protected amine can be deprotected under acidic conditions. Reagent grade, for research purpose. Please contact us for GMP-grade inquiries.

m-PEG-NH2, MW 2,000 is a monofunctional PEG polymer containing an amine terminus which can undergo coupling reaction with an activated NHS ester to form a stable amide bond. Reagent grade, for research purpose.