PEG

Acid-PEG4-Val-Cit-PAB-MMAE is a cleavable ADC linker featuring a carboxylic acid, a hydrophilic PEG spacer, and a Val-Cit-PAB dipeptide ligated to an MMAE payload. Carboxylic acids are reactive towards amines or alcohols while the Val-Cit-PAB motif is an enzyme-cleavable linker. This linker efficiently releases the toxin, MMAE, to target cells to cause cellular apoptosis.

Acid-PEG4-Val-Cit-PAB-MMAE is a cleavable ADC linker featuring a carboxylic acid, a hydrophilic PEG spacer, and a Val-Cit-PAB dipeptide ligated to an MMAE payload. Carboxylic acids are reactive towards amines or alcohols while the Val-Cit-PAB motif is an enzyme-cleavable linker. This linker efficiently releases the toxin, MMAE, to target cells to cause cellular apoptosis.

Acid-PEG4-Val-Cit-PAB-MMAE is a cleavable ADC linker featuring a carboxylic acid, a hydrophilic PEG spacer, and a Val-Cit-PAB dipeptide ligated to an MMAE payload. Carboxylic acids are reactive towards amines or alcohols while the Val-Cit-PAB motif is an enzyme-cleavable linker. This linker efficiently releases the toxin, MMAE, to target cells to cause cellular apoptosis.

Azide-PEG8-Val-Cit-PAB-MMAE is a cleavable ADC linker which contains an azide, a PEG spacer, a Val-Cit dipeptide, a PAB group, and an MMAE warhead. The azide is free to participate in click chemistry with terminal alkynes or strained cyclooctynes such as DBCO or BCN. The Val-Cit dipeptide is cleaved by cellular proteases within the cell to allow for efficient MMAE payload delivery via an elimination mechanism within the PAB structure.

Azide-PEG8-Val-Cit-PAB-MMAE is a cleavable ADC linker which contains an azide, a PEG spacer, a Val-Cit dipeptide, a PAB group, and an MMAE warhead. The azide is free to participate in click chemistry with terminal alkynes or strained cyclooctynes such as DBCO or BCN. The Val-Cit dipeptide is cleaved by cellular proteases within the cell to allow for efficient MMAE payload delivery via an elimination mechanism within the PAB structure.

Azide-PEG8-Val-Cit-PAB-MMAE is a cleavable ADC linker which contains an azide, a PEG spacer, a Val-Cit dipeptide, a PAB group, and an MMAE warhead. The azide is free to participate in click chemistry with terminal alkynes or strained cyclooctynes such as DBCO or BCN. The Val-Cit dipeptide is cleaved by cellular proteases within the cell to allow for efficient MMAE payload delivery via an elimination mechanism within the PAB structure.

C3-K2-E14 is a multi-ionizable amino-lipid featuring a central tertiary amine with two identical brranches and an n-propyl group. Each branch features a propanamide linking to a branched amine, each with two C14 arms and a hydroxyl. Ionizable lipids such as this may be applied in the development of lipid nanoparticles for drug delivery.

Acid-PEG4-C2-Boc, a linker compound based on polyethylene glycol (PEG) and alkyl/ether, is utilized in the synthesis of PROteolysis TArgeting Chimeras (PROTACs) for inhibiting the mechanistic Target of Rapamycin (mTOR)[1].

Dde Biotin-PEG4-DBCO is a PEG-based linker for PROTACs that connects two essential ligands, facilitating selective protein degradation via the ubiquitin-proteasome system within cells.