PEG

2-((2-(2-(2-methoxyethoxy)ethoxy)ethoxy)methyl)oxirane is a PEG linker with an epoxide ring and four ethylene glycol units linked together.

2-(t-Butyloxycarbonyl-PEG4)isoindoline-1,3-dione is a thalidomide-derivatized PROTAC linker including a t-butyl protecting group which can be removed under acidic conditions and a PEG4 spacer for increasing the solubility of the compound. Reagent grade, for research purpose. Please contact us for GMP-grade inquiries.

(1,3-dioxoisoindolin-2-yl)-PEG9-acid is a PROTAC linker featuring a thalidomide analog, PEG9 chain for hydrophilicity, and terminal carboxyl group, which can derivatize amine-containing molecules in the presence of activators such as EDC or HATU. Reagent grade, for research purpose. Please contact us for GMP-grade inquiries.

Bis-sulfone-PEG3-azide is a PEG linker consisting of two sulfone groups, three PEG units for hydrophilicity, and a terminal azide group for click chemistry reactions. The sulfone groups can be conjugated with thiol groups of proteins.

(1,3-dioxoisoindolin-2-yl)-PEG2-Boc serves as a PROTAC linker that can be used to make PROTACs. The Boc protection allows for controlled reactions without affecting the amine functionality. The PEG linker enhances the water solubility of the compound. Reagent grade, for research purpose. Please contact us for GMP-grade inquiries.

(1,3-dioxoisoindolin-2-yl)-PEG1-amine TFA salt is a PROTAC linker, which may be employed for the synthesis of PROTACs. The PEG unit improves solubility in aqueous environments. Reagent grade, for research purpose. Please contact us for GMP-grade inquiries.

Bis-PEG5-nitrile is a PEG linker containing two terminal nitrile groups, which can undergo hydrolysis, reduction and other reactions. The hydrophilic PEG spacer increases the solubility of compounds in aqueous media.

Pomalidomide-PEG8-Azide contains a cereblon ligand, hydrophilic PEG8 linker, and terminal azide. This product is ready for conjugation to target proteins for PROTAC R&D.

undecyl 6-(2-hydroxyethylamino)hexylcarbamate is an amino lipid featuring an ethanolamine head, a hexyl spacer and a carbamate linking it to an undecyl chain. This molecule is ionizable at its secondary amine, where it can also be alkylated to expand this structure.