PEG

Pomalidomide-amido-bis-benzoate-acid is a synthetic compound used in PROTAC technology, combining a Pomalidomide-based cereblon ligand with a bis-benzoate linker.

Pomalidomide-amido-bis-benzoate-aminooxy

m-PEG12-SPDP is a thiol reactive PEG linker used in PEGylation of proteins or peptides or other thiol molecules. The PEG12 spacer enhances the solubility of PEG siginificantly in an aqueous solution.

Azide-PEG-acid, MW 5,000 is a polyPEG reagent with an azide group with a terminal carboxylic acid. The azide group can react with alkyne, BCN, DBCO via Click Chemistry. The terminal carboxylic acid can react with primary amine groups in the presence of activators (e.g. HATU). The 5k PEG polymer increases the water-solubility of the molecule.

PEG 5,000

Azido-PEG-NHS ester, MW 2,000 (N3-PEG-SPA, MW 2,000) is a Click chemistry-reactive PEG active ester containing an azide group. Azido-PEG-NHS ester (N3-PEG-SPA) offers several benefits over the Azido-PEG-CH2CO2-NHS (N3-PEG-SCM). Azido-PEG-NHS ester is more stable in aqueous solutions compared to Azido-PEG-CH2CO2-NHS. It is a better choice for conjugations that are to be performed in aqueous solutions. Azido-PEG-NHS ester (N3-PEG-SPA) is also more stable for storage than Azido-PEG-CH2CO2-NHS (N3-PEG-SCM). Azido-PEG-NHS ester is reactive with primary amine but at a lower rate compared to Azido-PEG-CH2CO2-NHS.

Azido-PEG-NHS ester, MW 5,000 (N3-PEG-SPA, MW 5,000) is an active ester containing an azide group. Azide is reactive with alkyne, DBCO, BCN… through Click chemistry. Azido-PEG-NHS ester offers several benefits over the Azido-PEG-CH2CO2-NHS. Azido-PEG-NHS ester is more stable in aqueous solutions compared to Azido-PEG-CH2CO2-NHS. It is a better choice for conjugations that are to be performed in aqueous solutions. Azido-PEG-NHS ester (N3-PEG-SPA) is also more stable for storage than Azido-PEG-CH2CO2-NHS (N3-PEG-SCM). Azido-PEG-NHS ester is reactive with primary amine but at a lower rate compared to Azido-PEG-CH2CO2-NHS.

N-(Azido-PEG4)-N-Biotin-PEG4-NHS ester functions as a biotinylation reagent utilizing click chemistry through the azide group. The NHS ester can react with primary amines (-NH2) of amine-bearing molecules for labeling purposes.

N-(Propargyl-PEG2)-DBCO-PEG3-acid facilitates the creation of triazole linkages with azide-containing compounds using Click Chemistry. The carboxylic group can react with amine-containing entities using coupling agents like HATU for further conjugation.