PEG

N-(Mal-PEG2-carbonyl)-N-bis(PEG4-acid) is a branched PEG linker containing two terminal carboxylic groups which can react with amines in the presence of activators such as HATU. The maleimide reacts with a thiol group to form a covalent bond. The PEG units increase the aqueous solubility of the molecule.

3-(2,5-Dioxo-2,5-dihydro-1H-pyrrol-1-yl)propanehydrazide hydrochloride

1-(3-Aminopropyl)-1H-pyrrole-2,5-dione hydrochloride

6-(2,5-Dioxo-2,5-dihydro-1H-pyrrol-1-yl)hexanehydrazide hydrochloride

4-N-Maleimidobenzoicacid-NHS is a PEG linker that finds utility in bioconjugation endeavors and protein labeling ventures. Specifically designed for selective reaction with thiol groups, the maleimide group establishes covalent linkages, thereby facilitating the coupling of proteins, peptides, or diverse molecules to thiol-bearing biomolecules. The NHS ester is able to react specifically and efficiently with primary amines (e.g. the side chain of lysine residues or aminosilane-coated surfaces) at neutral or slightly basic conditions to form a covalent bond.

3-(Pyridin-2-yldisulfanyl)propanehydrazide

2,5-Dioxopyrrolidin-1-yl 3-(3-(2,5-dioxo-2,5-dihydro-1H-pyrrol-1-yl)propanamido)propanoate represents a heterobifunctional PEG linker, featuring a terminal NHS ester that can be used to label amine compounds and maleimide group for reactions with thiol groups.

Tert-butyl (2-(pyridin-2-yldisulfanyl)ethyl)carbamate consists of a tert-butyl group, where the protected amine can be deprotected under mild acidic conditions, and the other part of the molecule may act as a thiol-specific labeling reagent, commonly used in reversibly binding cysteine residues on proteins.

(S)-2-(2-Aminopropanamido)acetic acid