PEG

N-Boc-Tri-(Azide-PEG4-ethoxymethyl)-methane represents a crosslinker consisting of six azide click chemistry groups that readily react with strained cyclooctynes and terminal alkynes. The hydrophilic PEG spacers increase solubility in aqueous media. The Boc-protected amine can be deprotected under acidic conditions. Reagent grade, for research purpose. Please contact us for GMP-grade inquiries.

Cholesterol esters (CEs) can modulate membrane fluidity and bilayer thickness upon interacting with triacylglycerols (TAGs) and phospholipids (PLs). Unsaturated esters such as these have been shown to affect the liquid crystalline phases of these type of lipids. Formulation of CEs into lipid nanoparticles may serve to tune the physical properties of lipid nanoparticles for delivery applications. Reagent grade, for research purpose. Please contact us for GMP-grade inquiries.

Cy5-PEG-CH2COOH, MW 5,000 is a polyPEG containing a DSPE phospholipid, a Cy5 dye, and a non-activated carboxylic acid. The hydrophobic properties of the DSPE allow for the encapsulation and congregation of other hydrophobic drugs. The hydrophilic polyPEG chain increases the water solubility of the overall compound allowing for the delivery of the drug. The absorbance/emission maximum is 646/662 nm. Reagent grade, for research purpose. Reagent grade, for research purpose. Please contact us for GMP-grade inquiries.

A multichargeable cholesterol carbamate derivative that has been used in conjunction with DOPE for the formulation of cationic liposomes to deliver siRNA. Reagent grade, for research purpose. Please contact us for GMP-grade inquiries.

DBCO-PEG4-Amido-tri-(PEG6-TCO)-methane serves as a clickable branched linker consisting of a terminal DBCO commonly used for copper-free Click Chemistry reactions and three terminal TCO groups that readily react with tetrazine-containing compounds. The PEG4 chain linking the DBCO to the amido groups and the PEG6 linker connecting the TCO groups both enhance the solubility of the overall molecule in aqueous media. Reagent grade, for research purpose. Please contact us for GMP-grade inquiries.

SGK3-PROTAC1 is a degradation-inducing compound that combines the 308-R SGK inhibitor with the VH032 VHL binding ligand in a PROTAC conjugate. This compound is designed to facilitate the degradation of SGK3 through targeted interactions.

BODIPY FL VH032 stands as a high-affinity VHL fluorescent probe. It proves invaluable in time-resolved fluorescence resonance energy-transfer (TR-FRET) assays, offering a robust tool for the efficient high-throughput identification and characterization of VHL ligands.

VH032, a VHL ligand, plays a crucial role in recruiting the von Hippel-Lindau (VHL) protein. Functioning as an inhibitor of VHL/HIF-1α interactions, VH032 exhibits a Kd that underscores its efficacy in PROTAC-mediated processes.

HaloPROTAC3 represents a fusion of E3 ligands, a linker spanning 16 atoms in length, and a degrading agent targeting fusion proteins with the HaloTag.