PEG

Methyltetrazine-PEG12-Amine-HCl salt is an aqueous souluble PEG linker containing a free amine and a methyltetrazine group. Methyl group improves the stability and hydrophilic PEG spacer increases water-solubility. Methyltetrazine enable fast click reaction with TCO (trans-cycloctene), the amine (NH2) group is reactive with carboxylic acid containing molecule in the presence of reagnet such as EDC or HATU. Reagent grade, for research purpose. Please contact us for GMP-grade inquiries.

Mal-PEG2-Amide is a PEG linker with a maleimide group which can react with a thiol group to form a covalent bond, enabling the connection of biomolecule with a thiol. Reagent grade, for research purpose. Please contact us for GMP-grade inquiries.

Aminooxy-PEG2-amine is an aqueous soluble crosslinker. The aminooxy group can be used in bioconjugation. It reacts with an aldehyde to form an oxime bond, if a reductant is used, it will form a hydroxylamine linkage. The amino group is reactive with carboxylic acids, activated NHS esters, carbonyls (ketone, aldehyde) etc. Reagent grade, for research purpose. Please contact us for GMP-grade inquiries. Aminooxy compounds are very reactive and sensitive; they cannot be stored for long term. Immediate use (within 1 week) is highly recommended.

Aminooxy-PEG1-amine is a chemical reagent containing an aminooxy group and a primary amine. The aminooxy group is reactive with an aldehyde to form an oxime bond. If a reductant is used, it will form a hydroxylamine linkage. The amino group is reactive withactivated NHS esters, or carboxylic acid in the presence of coupling reagent EDC. Reagent grade, for research purpose. Please contact us for GMP-grade inquiries. Aminooxy compounds are very reactive and sensitive; they cannot be stored for long term. Immediate use (within 1 week) is highly recommended.

Propargyl-PEG13-t-butyl ester enables Click Chemistry reactions with azide-bearing compounds or biomolecules to form stable triazole linkages; copper is required as a catalyst. The t-butyl protection can be removed under acidic conditions. The PEG units improve the hydrophilicity of the molecule in aqueous media. Reagent grade, for research purpose. Please contact us for GMP-grade inquiries.

SPDP-PEG11-SPDP is a PEG linker with SPDP moiety on both sides. The SPDP is an amine and thiol reactive crosslinker. It is also membrane permeable, allowing it to participate in intracellular crosslinking reactions. The hydrophilic PEG linker increases the solubility of the compound in aqueous media. Reagent grade, for research purpose. Please contact us for GMP-grade inquiries.

(S, R, S)-AHPC-PEG4-tosyl is a PROTAC linker that incorporatess an E3 ligase ligand with a PEG4 linker to empower PROTAC drug research & discovery. PEG4 spacer increases the compound's hydrophility. Tosyl group is reactive with amine or other nucleophiles. Reagent grade, for research purpose. Please contact us for GMP-grade inquiries.

Mal-PEG4-trimethylammonium chloride Reagent grade, for research purpose. Please contact us for GMP-grade inquiries.

Pomalidomide is the third-generation immunomodulatory agent, functions through interacting with the E3 ligase cereblon and induces degradation of essential Ikaros transcription factors. Reagent grade, for research purpose. Please contact us for GMP-grade inquiries.