PEG

endo-BCN-PEG3-Gly represents an ADC linker featuring a BCN group, a hydrophilic PEG3 linker, and glycine residue. The BCN group is a click chemistry handle that readily reacts with azide groups on a target molecule to form stable triazole linkages. The PEG units enhance the aqueous solubility of the compound and may assist in fine-tuning DMPK properties. This compound may be applied to the synthesis of antibody-drug conjugates.

BP Lipid 422 is a symmetric polar lipid featuring a two unsaturated oleic acid tails and useful maleimide linker. This compound may be used for bioconjugation and surface modification applications, or as a useful synthetic scaffold for novel lipids. Reagent grade, for research purpose. Please contact us for GMP-grade inquiries.

Boc-Gly-PEG3-amine works as a PEG linker featuring an amino group and a Boc-protected amino group. Amino (NH2) group is reactive with carboxylic acids, and activated NHS esters. The Boc group can be deprotected under mild acidic conditions to form the free amine. Reagent grade, for research purpose. Please contact us for GMP-grade inquiries.

Benzyloxy carbonyl-PEG5-acid functions as a linker with a benzyl protecting group and a carboxylic acid. The carboxylic acid can undergo reactions with primary amines via activators (EDC or HATU). The benzyl protecting group can be removed via hydrogenolysis. Reagent grade, for research purpose. Please contact us for GMP-grade inquiries.

2'-O-TBDMS-7-O-(Azido-PEG4)-Paclitaxel

bis-Mes-PEG, MW 5,000 represents a homobifunctional polyPEG reagent containing two methanesulfonyls, which act as good leaving groups. The polymer can be used for nucleophilic SN2 substitution reactions. The 5k polyPEG enhances the hydrophilicity of the compound.

AMCA-PEG1-NHS ester is the AMCA dye linker containing a NHS ester group and a hydrophilic PEG spacer arm. The NHS ester allows the dye to react with primary amines and the hydrophilic PEG spacer arm increases water solubility as well as membrane permability. This dye is used for protein and peptide labeing. The structure is similar to commercial AMCA-X-SE with better solubility. Reagent grade, for research purpose. Please contact us for GMP-grade inquiries.

Iodoacetamido-PEG23-azide represents a polyPEG reagent comprised of an iodoacetamide moiety that is commonly used to covalently bind with the thiol group of cysteine so the protein cannot form disulfide bonds. The azide moiety can react with alkyne, BCN, DBCO via Click Chemistry. The long PEG chain enhances the water-solubility of the compound. Reagent grade, for research purpose. Please contact us for GMP-grade inquiries.

Iodoacetamido-PEG23-azide represents a polyPEG reagent comprised of an iodoacetamido moiety that is employed to covalently bind with the thiol group of cysteine so the protein cannot form disulfide bonds. The azide moiety participates in Click Chemistry with alkyne, BCN, DBCO. The long PEG arm improves the hydrophilicity of the molecule. Reagent grade, for research purpose. Please contact us for GMP-grade inquiries.