PEG

Mal-PEG5-amine TFA salt is a PEG linker containing a maleimide group and an amine group. The hydrophilic PEG spacer increases solubility in aqueous media. The amine group is reactive with carboxylic acids, activated NHS esters, carbonyls (ketone, aldehyde) etc. The maleimide group will react with a thiol group to form a covalent bond, enabling the connection of biomolecule with a thiol. Reagent grade, for research purpose. Please contact us for GMP-grade inquiries.

N-(Methylamino-PEG3)-NH-PEG3-acid is a branched PEG linker containing a carboxylic acid with a methylamine group. The hydrophilic PEG spacer increases solubility in aqueous media. The amino group is reactive with carboxylic acids, activated NHS esters, carbonyls, etc. The methylamine group is reactive with carboxylic acids, carbonyls (ketone, aldehyde) etc. The terminal carboxylic acid can react with primary amine groups in the presence of activators (e.g. EDC, or HATU) to form a stable amide bond. Reagent grade, for research purpose. Please contact us for GMP-grade inquiries.

Pomalidomide-PEG5-Azide, I is a PROTAC linker that incorporatess the Pomalidomide based cereblon ligand and 4-unit PEG linker used in PROTAC technology.Azide enable click chemistry with Alkyne, DBCO or BCN molecules. Reagent grade, for research purpose. Please contact us for GMP-grade inquiries.

(S, R, S)-AHPC-PEG3-acid is a PROTAC linker that incorporates an E3 ligase ligand with a PEG3 linker to empower PROTAC drug research & discovery. Reagent grade, for research purpose. Please contact us for GMP-grade inquiries.

Mal-PEG5-trimethylammonium chloride Reagent grade, for research purpose. Please contact us for GMP-grade inquiries.

(S, R, S)-AHPC-PEG8-acid is a synthetic PROTAC linker that incorporatess an E3 ligase ligand with a PEG8 linker to empower PROTAC drug R&D. PEG8 increases the compound's aqueous solubility. Acid group is reactive with amine containing molecule. Reagent grade, for research purpose. Please contact us for GMP-grade inquiries.

N-(Azido-PEG3)-N-(BocNH-PEG2) is a branched PEG linker with two terminal azide group and a Boc-protected amino group. The azide groups enable PEGylation via Click Chemistry. The Boc group can be deprotected under mild acidic conditions to form the free amine. Reagent grade, for research purpose. Please contact us for GMP-grade inquiries.

(S, R, S)-AHPC-pentanoic-acid is a PROTAC linker that incorporates an E3 ligase ligand with a linker to empower PROTAC drug research & discovery. It can react with amine containing molecules. Reagent grade, for research purpose. Please contact us for GMP-grade inquiries.

Thalidomide-O-PEG4-Acid is a PROTAC linker that can react with Amine containing moiety in the presence of Activator EDC or HATU Reagent grade, for research purpose. Please contact us for GMP-grade inquiries.