PEG

Biotin-PEG12-Picolyl azide features an azide group for copper-catalyzed azide-alkyne cycloaddition (CuAAC) with linear alkyne-containing molecules, with the picoyl azide moiety increasing the efficiency and speed of the CuAAC reaction for improved biocompatible labeling. It can also participate in strain-promoted alkyne-azide cycloaddition (SPAAC) with DBCO or BCN groups without a copper catalyst.

2,3-dihydroxypropyl carbamate-PEG-m, MW 1,000

Methyltetrazine-amido-N-bis(PEG4-DBCO) represents a PEG derivative that includes a methyltetrazine group and two DBCO groups. The inverse-electron demand Diels-Alder cycloaddition reaction of TCO with tetrazines is the fastest bioorthogonal reaction with exceptional selectivity. DBCO is a click chemistry handle that is frequently used to conjugate with azides on target molecules. The PEG4 chains increase the water solubility of the compound.

nonadeca-1,18-dien-10-yl 4-bromobutanoate

Methyltetrazine-PEG7-maleimide serves as a bifunctional PEG linker comprised of methyltetrazine, which is reactive toward trans-cyclooctenes, and maleimide, which is reactive towards thiol-bearing moieties. The additional methyl on the methyltetrazine enhances the stability of the group. The PEG link enhances solubility in aqueous media.

DOTA-PEG5-TCO is a PEG linker containing DOTA and TCO moieties. TCO is a click chemistry handle that readily reacts with tetrazine groups on a target molecule. The DOTA group can be ionized and is susceptible to chelating di- and trivalent cations. DOTA can also be used for imaging diagnostic techniques.

3,7,11-trimethyldodecyl 6-bromohexanoate

m-PEG2-alcohol

3,4-Dibromo-Mal-PEG2-Acid constitutes a PEG linker with a dibromomaleimide group and an acid group. The dibromomaleimide group allows for two points of substitution due to the two bromine atoms. Dibromo-Maleimide is sensitive to high temperature and light. The carboxylic acid can react with primary amines in the presence of coupling agents such as EDC and HATU. The hydrophilic PEG linker increases the water solubility of compounds in aqueous media.