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Dovitinib RIBOTAC is a selective RNA degrader designed to target and cleave pre-miR-21, offering enhanced potency and specificity in RNA degradation.

PROTAC HER3 Degrader-8 is a bifunctional molecule designed to induce the degradation of HER3 protein in vitro and in cellular assays, useful for investigating pathways involving HER family proteins.

SJF-0628 is a PROTAC designed to selectively degrade mutant BRAF proteins. It targets specific BRAF variants, making it useful for studying conditions linked to RAF protein aggregation, accumulation, or persistent activation.

PROTAC EGFR Degrader 2 is a highly potent compound that effectively targets EGFR for degradation. It demonstrates strong antiproliferative properties and can be utilized in the synthesis of nitroreductase-responsive PROTACs.

HDAC6 Degrader-3 is a selective compound that facilitates HDAC6 degradation through ternary complex formation and the ubiquitin-proteasome system. It shows significant selectivity for HDAC6 over HDAC1 and induces marked hyperacetylation of α-tubulin.

CMP98 is a PROTAC that does not promote VHL degradation and serves as a negative control for CM11. It features two von Hippel-Lindau ligands within its active structure.

NJH-2-056 is a deubiquitinase-targeting chimera (DUBTAC) that connects the OTUB1 recruiter EN523 with the CFTR chaperone lumacaftor. This compound facilitates studies on protein regulation and folding mechanisms associated with cystic fibrosis.

PZ703b is a PROTAC designed to degrade Bcl-xl, promoting apoptosis and suppressing the proliferation of cancer cells. This compound serves as a valuable tool for investigating mechanisms related to bladder cancer.

PROTAC α-synuclein degrader 5 is a selective small-molecule degrader targeting α-synuclein aggregates. It features the probe molecule sery308 along with E3 ligase ligands, facilitating significant degradation activity. This compound is a valuable resource for research in neurological disorders.