PEG

Thalidomide-O-PEG4-NHS ester (Legacy Tebubio ref. 282T18830). Thalidomide-O-PEG4-NHS ester is a polyethylene glycol (PEG)-based linker commonly used in the synthesis of proteolysis-targeting chimeras (PROTACs)[1].

Thiol-PEG8-alcohol (Legacy Tebubio ref. 282T18843). Thiol-PEG8-alcohol is a PEG-based linker for PROTACs, joining two essential ligands crucial for forming PROTAC molecules and enabling selective protein degradation by leveraging the ubiquitin-proteasome system within cells.

THP-PEG4-Pyrrolidine(N-Me)-CH2OH (Legacy Tebubio ref. 282T18847). THP-PEG4-Pyrrolidine(N-Me)-CH2OH, a PEG-based PROTAC linker, aids in the synthesis of PROTAC K-Ras Degrader-1[1].

Tri(Amino-PEG3-amide)-amine (Legacy Tebubio ref. 282T18857). Tri(Amino-PEG3-amide)-amine, a polyethylene glycol (PEG)-derived linker, is utilized in the synthesis of proteolysis-targeting chimeric molecules (PROTACs)[1].

Tri(Amino-PEG4-amide)-amine (Legacy Tebubio ref. 282T18858). Tri(Amino-PEG4-amide)-amine is a polyethylene glycol (PEG)-based linker compound used in the synthesis of proteolysis-targeting chimeras (PROTACs)[1].

UV Cleavable Biotin-PEG2-Azide (Legacy Tebubio ref. 282T18866). UV Cleavable Biotin-PEG2-Azide, a PEG-based PROTAC linker, enables the synthesis of PROTACs[1].

(S,R,S)-AHPC-PEG5-COOH (Legacy Tebubio ref. 282T18872). (S,R,S)-AHPC-PEG5-COOH (VH032-PEG5-COOH) is a synthetic E3 ligase ligand-linker conjugate developed for PROTAC technology, comprising the (S,R,S)-AHPC-based VHL ligand and a 5-unit PEG linker [1].

PEG400 (Legacy Tebubio ref. 282T19506). PEG400 (Polyethylene glycol 400) is a polymer formed from repeating units of ethylene glycol that is water soluble, low immunogenicity, and biocompatible. PEG400 is a neutral polymer with a molecular weight of 400.

Propargyl-PEG3-azide (Legacy Tebubio ref. 282T19974). Propargyl-PEG3-amine is a PEG derivative containing a propargyl group and an amino group. The propargyl group can be reacted with azide-bearing compounds or biomolecules via copper-catalyzed azide-alkyne Click Chemistry to yield a stable triazole linkage. PEG Linkers are useful in the development of antibody-drug conjugates.