PEG

FmocNH-PEG4-t-butyl ester (Legacy Tebubio ref. 282T39619). FmocNH-PEG4-t-butyl ester is a PEG-based linker for PROTACs that connects two essential ligands, facilitating the selective degradation of proteins through the ubiquitin-proteasome system within cells.

Benzyl-PEG12-alcohol (Legacy Tebubio ref. 282T39689). Benzyl-PEG12-alcohol is a PEG-based linker for PROTACs, connecting two essential ligands to form PROTAC molecules. This linker facilitates selective protein degradation by utilizing the ubiquitin-proteasome system within cells.

Pomalidomide 4'-PEG3-azide (Legacy Tebubio ref. 282T39806). Pomalidomide 4'-PEG3-azide is a chemically synthesized E3 ligase ligand-linker conjugate that incorporates the cereblon ligand derived from Pomalidomide, along with a linker. This compound is utilized in the synthesis of iRucaparib-TP3 (Compound 3), an effective PARP1 degrader developed through the PROTAC strategy and derived from Rucaparib.

Pomalidomide-amino-PEG4-NH2 hydrochloride (Legacy Tebubio ref. 282T39867). Pomalidomide-amino-PEG4-NH2 hydrochloride, a synthesized E3 ligase ligand-linker conjugate, incorporates the cereblon ligand derived from Pomalidomide, along with a linker commonly employed in PROTAC technology.

Pomalidomide-PEG6-NH2 hydrochloride (Legacy Tebubio ref. 282T39875). Pomalidomide-PEG6-NH2 hydrochloride is a compound resulting from the synthesis of an E3 ligase ligand-linker conjugate, combining the cereblon ligand derived from Pomalidomide with a 6-unit PEG linker, specifically designed for application in PROTAC technology.

Thalidomide-Piperazine-PEG3-NH2 (Legacy Tebubio ref. 282T39895). Thalidomide-Piperazine-PEG3-NH2 is a synthesized E3 ligase ligand-linker conjugate that combines a Thalidomide-based cereblon ligand with a linker commonly used in [PROTAC] technology, functioning as an E3 ligase recruiter.

DBCO-PEG4-MMAF (Legacy Tebubio ref. 282T39897). DBCO-PEG4-MMAF is an antibody-drug conjugate (ADC) component that exhibits potent antitumor activity. It combines the tubulin polymerization inhibitor MMAF with a cleavable linker, DBCO-PEG4, to target cancer cells effectively.

MP-PEG4-Val-Lys-Gly-7-MAD-MDCPT (Legacy Tebubio ref. 282T39941). MP-PEG4-Val-Lys-Gly-7-MAD-MDCPT is a Camptothecin-linker and a drug-linker conjugate for antibody-drug conjugate (ADC).

Pomalidomide-amino-PEG3-NH2 hydrochloride (Legacy Tebubio ref. 282T39953). Pomalidomide-amino-PEG3-NH2 hydrochloride is an E3 ligase ligand-linker conjugate containing a pomalidomide-based cereblon ligand and a linker, which can be used to synthesize PROTACs.