PEG

N-Me-N-bis(PEG4-acid) HCl salt is a crosslinker linker containing two PEG4-acid groups. The two terminal carboxylic acid groups can react with primary amines in the presence of activators such as EDC and HATU to form stable amide bonds. The hydrophilic PEG linkers increase the water solubility of the compound. The water solubility properties of the PEG linker are enhanced with longer PEG chains. Reagent grade, for research purpose. Please contact us for GMP-grade inquiries.

Propargyl-PEG10-acid is a propargyl PEG linker with a terminal carboxylic acid. The terminal carboxylic acid forms amide bonds with primary amines; activators (EDC or HATU) will be needed. The propargyl group can react with azide-bearing compounds to form stable triazole bonds. Reagent grade, for research purpose. Please contact us for GMP-grade inquiries.

Bis-Tos-(2-hydroxyethyl disulfide) contains a cleavable disulfide bond and two tosyl moieties. Tosyl is a good leaving group and can be replaces by a nucleophiles. The disulfide bond can be cleaved via reduction. Reagent grade, for research purpose. Please contact us for GMP-grade inquiries.

THP-PEG4 is PEG linker containing a THP protecting group and a terminal hydroxyl. THP is an acid labile, alcohol protecting group. The hydroxyl group can react to further derivatize the compound. The hydrophilic PEG chain increases the water solubility of the compound in aqueous environments. The water solubility properties of the PEG linker are enhanced with longer PEG chains. Reagent grade, for research purpose. Please contact us for GMP-grade inquiries.

Biotin-PEG3-amine is reactive with NHS ester or carboxylic acid in the presence of EDC or HATU. PEG3 increases aqueous solubility of the molecules conjugated to the biotin compound. It also helps to minimize steric hindrance involved with the binding to avidin molecules. Reagent grade, for research purpose. Please contact us for GMP-grade inquiries.

Bis-propargyl-PEG10 is reactive with azide-bearing compounds or biomolecules in copper catalyzed Click Chemistry. By introducing PEG units into the molecule, the solubility of the compound in aqueous environment can be improved. Reagent grade, for research purpose. Please contact us for GMP-grade inquiries.

Propargyl-PEG14-alcohol is a propargyl linker which enables Click Chemistry with azide compounds to yield stable triazole linkage. The PEG spacer enhances the hydrophilicity of the molecule in aqueous media. Reagent grade, for research purpose. Please contact us for GMP-grade inquiries.

Hydroxy-PEG3-SS-PEG3-alcohol contains two terminal hydroxyl groups and a cleavable disulfide bond. The disulfide bond can be cleaved via reduction reactions using Dithiothreitol (DTT) reagent. The hydroxyl groups can be reacted to further derivatize the compound. The hydrophilic PEG chains increase the water solubility of the compound in aqueous media. The water solubility properties of the PEG linker are enhanced with longer PEG chains. Reagent grade, for research purpose. Please contact us for GMP-grade inquiries.

Propargyl-PEG4-methylamine is a PEG linker that can be react with azide compounds in copper catalyzed azide-alkyne Click Chemistry reactions. The methylamine group is reactive with carboxylic acids, activated NHS esters, carbonyls (ketone, aldehyde) etc. The PEG spacer increases hydrophilicity of the linker in aqueous environment. Reagent grade, for research purpose. Please contact us for GMP-grade inquiries.