Peptides & Amino Acids

Protirelin – Thyrotropin-releasing hormone (TRH) (CAS: 24305-27-9) Thyrotropin-releasing hormone (TRH) Thyrotropin-releasing hormone (TRH) is a tripeptide hypothalamic regulatory hormone that regulates the release of thyroid-stimulating hormone (TSH), as well as prolactin (for breasts growth and milk production during and after pregnancy). To obtain thyrotropin-releasing hormones, 6 pro-TRH peptides have first to be obtained from the larger preproTRH precursor (UniProt: P20396). These octapeptides are then cleaved between Arginine/Glutamine and Glutamine/Lysine residues to release 6 Gln-His-Pro-Gly peptides that will be enzymatically converted in pGln-His-Pro-NH2 peptides (pGln representing pyroglutamine). After TRH maturation (1) in neurons located in the pituitary gland, the hormone will be transported along axons (2) to reach the hypophyseal portal system via exocytosis (3). Once the thyrotrophs reached, thyrotropin-releasing hormone binds TRH-receptor (4) to enable TSH syn

Protirelin – Thyrotropin-releasing hormone (TRH) (CAS: 24305-27-9) Thyrotropin-releasing hormone (TRH) Thyrotropin-releasing hormone (TRH) is a tripeptide hypothalamic regulatory hormone that regulates the release of thyroid-stimulating hormone (TSH), as well as prolactin (for breasts growth and milk production during and after pregnancy). To obtain thyrotropin-releasing hormones, 6 pro-TRH peptides have first to be obtained from the larger preproTRH precursor (UniProt: P20396). These octapeptides are then cleaved between Arginine/Glutamine and Glutamine/Lysine residues to release 6 Gln-His-Pro-Gly peptides that will be enzymatically converted in pGln-His-Pro-NH2 peptides (pGln representing pyroglutamine). After TRH maturation (1) in neurons located in the pituitary gland, the hormone will be transported along axons (2) to reach the hypophyseal portal system via exocytosis (3). Once the thyrotrophs reached, thyrotropin-releasing hormone binds TRH-receptor (4) to enable TSH syn

Haemagglutinin (HA) peptide YPYDVPDYA – HA Tag SB-PEPTIDE offers Human influenza hemagglutinin (HA) tag YPYDVPDYA, which is a well characterized 9 amino acids synthetic peptide deriving from an epitope of the original influenza hemagglutinin protein. Haemagglutinin surface fusion glycoprotein for viral entry Haemagglutinin (HA) (UniProt : P03437) is an envelope protein present in the viral membrane of influenza viruses. HA forms a trimer containing structurally distinct regions and an intact HA0 polypeptide composed of two subunits, called HA1 and HA2, connected by one disulfide bridge. Haemagglutinin (HA) 3D structure. HA tag SB-PEPTIDE_CAS: 92000-76-5 To initiate their fusion with their cellular hosts, influenza viruses first bind to sialic acids at the surface of respiratory epithelial cells. Following this interaction, they will enter the cell via endocytosis. Endosomal uptake of influenza virus - HA tag SB-PEPTIDE_CAS: 92000-76-5 Due to proton pumps on t

Haemagglutinin (HA) peptide YPYDVPDYA – HA Tag SB-PEPTIDE offers Human influenza hemagglutinin (HA) tag YPYDVPDYA, which is a well characterized 9 amino acids synthetic peptide deriving from an epitope of the original influenza hemagglutinin protein. Haemagglutinin surface fusion glycoprotein for viral entry Haemagglutinin (HA) (UniProt : P03437) is an envelope protein present in the viral membrane of influenza viruses. HA forms a trimer containing structurally distinct regions and an intact HA0 polypeptide composed of two subunits, called HA1 and HA2, connected by one disulfide bridge. Haemagglutinin (HA) 3D structure. HA tag SB-PEPTIDE_CAS: 92000-76-5 To initiate their fusion with their cellular hosts, influenza viruses first bind to sialic acids at the surface of respiratory epithelial cells. Following this interaction, they will enter the cell via endocytosis. Endosomal uptake of influenza virus - HA tag SB-PEPTIDE_CAS: 92000-76-5 Due to proton pumps on t

Huwentoxin IV (HwTx-IV) is a neurotoxin that was originally isolated from Haplopelma schmidti (Chinese bird spider). This lethal neurotoxin acts selectively on tetrodotoxin-sensitive (TTX-S) voltage-gated sodium channels, with an IC50 of 30 nM in rat DRG neurons. It preferentially inhibits neuronal voltage-gated sodium channel subtype hNav1.7 (SCN9A, IC50 is 26 nM), rNav1.2 (SCN2A, IC50 is 150 nM), and rNav1.3 (SCN3A, IC50 is 338 nM), compared with muscle subtypes rNav1.4 (SCN4A) and hNav1.5 (SCN5A) (IC50 is > 10 µM). Huwentoxin IV inhibits the activation of sodium channels by trapping the voltage sensor of domain II of the site 4 in the inward, closed configuration. Cy5-Huwentoxin IV is a fluorescently tagged version of Huwentoxin IV.

Cy5-ProTx-II is a fluorescently labeled ProTx-II, a famous Nav1.7 blocker. The wild type ProTx-II blocks Nav1.7 with an IC50 value of around 300 pM, Nav1.2, Nav1.5 and Nav1.6 with IC50 values of 41 nM, 79 nM and 26 nM respectively. The Cy5-ProTx-II version developed by Smartox has potent Nav1.7 blocking activity. It was shown to fully block Nav1.7 at 100 nM concentration.

CAS Number: 50-57-7Molecular Weight: 1056Salt Form: AcetatePurity: >96%Sequence (3-letter): Cys-Tyr-Phe-Gln-Asn-Cys-Pro-Lys-Gly-NH2 (Cys 1- Cys 6)Sequence (1-letter): CYFQNCPKG-NH2 (Cys 1)( Cys 6)Storage: -20 °C or belowVasopressin [Lys8] aka Lysipressin is an antidiuretic hormone found in some mammals and marsupials that induces contraction of smooth muscle.

Beta Amyloid peptides, also called Amyloid beta peptides (Abeta peptides) are the main component of amyloid peptide plaques in the brain of patients with Alzheimer's disease. sb-PEPTIDE provides a broad range of chemically synthesized amyloid beta peptides for Alzheimer's disease research. We supply Abeta peptides of different lengths and point-mutated versions. Do not hesitate to contact us for any information. 

Angiotensin-converting enzyme 2 (ACE2) is an enzyme involved in the cardiovascular system by decreasing arterial pressure by catalyzing the conversion of angiotensin II to angiotensin (1-7). Angiotensin II is a vasoconstrictor and angiotensin (1-7) is a vasodilatator. This effect makes ACE2 a therapeutic target for cardiovascular disease. Otherwise, ACE2 also corresponds to a receptor allowing the coronavirus (SARS-CoV-2) to enter the host cell. sb-PEPTIDE provides ACE2 as an overlaped library with biotinylated peptides of 15 amino acids with an overlap of 11 amino acids. 1 peptide per well.