Peptides & Amino Acids

Osteocalcin (OC) is a 49 amino acid peptide found exclusively in bone tissue and is highly conserved among species. It is a vitamin K- and D-dependent protein produced by osteoblasts, osteocytes and odontoblasts. It is deposited in extracellular bone matrix and is found in the serum. Serum osteocalcin, hydrolysed in the kidney and liver, is considered a specific marker of osteoblast activity and bone formation rate. It may be involved in regulation of osteoblast function, regulation of bone turnover and/or mineralization.

This peptide, a nuclear localization signal (NLS) peptide, is derived from the Large T antigen residues 47 to 56 (PKKKRKVEDP). It can be used to tag DNA. DNA tagged to this peptide efficiently translocates into the cell nucleus.

Akt is a serine/threonine kinase that enhances cell proliferation and inhibits apoptosis when activated. Akt associates with PI(3,4,5)P3) at the cell membrane through its pleckstrin homology domain and is activated through phosphorylation. 3-Phosphoinositide-dependent kinase-1 (PDK1) has been shown to first phosphorylate Akt at Thr308, then a second kinase phosphorylates Akt at position Ser473. In turn, Akt phosphorylates a host of proteins including the proapoptotic proteins BAD and pro-caspase-9, GSK3, p21WAF1, MDM2, and the forkhead (FKHR) family of transcription factors.

NFkB p65 phospho S276 peptide for use in control assays with purified antibodies Anti-NFkB p65 pS279 (p/n 100-401-264 and 600-401-264). Also available NFkB p65 non-phospho S276 peptide (p/n 000-000-264NP).

NFkB p65 non-phospho S276 peptide for use in control assays with purified antibodies Anti-NFkB p65 pS279 (p/n 100-401-264 and 600-401-264). Also available NFkB p65 phospho S276 peptide (p/n 000-000-264).

NFkB p65 phospho S529 peptide for use in control assays with purified antibodies Anti-NFkB p65 pS529 (p/n 100-401-266). Also available NFkB p65 non-phospho S529 peptide (p/n 000-000-266NP).

NFkB p65 non-phospho S529 peptide for use in control assays with purified antibodies Anti-NFkB p65 pS529 (p/n 100-401-266). Also available NFkB p65 phospho S529 peptide (p/n 000-000-266).

ATM non-phospho S1981 peptide for use in control assays with purified antibody Anti-ATM S1981 non-phospho (p/n 600-401-398). Also available ATM phospho S1981 peptide (p/n 000-000-400) and Anti-ATM pS1981 phospho antibodies (p/n 200-301-400 and 600-601-400).

ATM phospho S1981 peptide for use in control assays with purified antibodies Anti-ATM pS1981 (p/n 200-301-400 and 600-601-400). Also available ATM non-phospho S1981 peptide (p/n 000-000-398) and Anti-ATM non-phospho S1981 (p/n 600-401-398).