Lentivirus

500 ul of VSV-G(Luc/GFP) particles Luc/GFP Dual reporter (High Titer)

The pandemic coronavirus disease 2019 (COVID-19) is caused by Severe Acute Respiratory Syndrome Coronavirus 2 (SARS-CoV-2). As the first step of the viral replication, the virus attaches to the host cell surface before entering the cell. The viral Spike protein recognizes and attaches to the Angiotensin-Converting Enzyme 2 (ACE2) receptor found on the surface of type I and II pneumocytes, endothelial cells, and ciliated bronchial epithelial cells. Drugs targeting the interaction between the Spike protein of SARS-CoV-2 and ACE2 may offer protection against the viral infection. A variant called B.1.1.529 BA.1 (also known as the Omicron Variant) was identified in South Africa in November of 2021. This variant has a large number of mutations that allow the virus to spread more easily and quickly than other variants. A sub-lineage of BA.1 with an R346K substitution in the spike protein is classified as B.1.1.529 BA.1.1. The Spike (B.1.1.529 BA.1.1, Omicron Variant R346K) (SARS-CoV-2) Pseudo

The Early growth response 1 (EGR1, also known as ZNF268 or NGFi-A) Promoter Luciferase Reporter Lentiviruses are replication incompetent, HIV-based, VSV-G pseudotyped lentiviral particles that are ready to be transduced into almost all types of mammalian cells, including primary and non-dividing cells. The particles contain a firefly luciferase gene driven by the human EGR1 promoter (~1.3 kb, Figure 1). After transduction, activation of the EGR1 promoter in the target cells can be monitored by measuring the luciferase activity.  <img src="{{media url="wysiwyg/Lentivirus/78664.png"}}" alt="" width="352" height="262" /> Figure 1. Schematic of the lenti-vector used to generate the EGR1 Promoter Luciferase Reporter Lentivirus.

Please note this product may be subject to fees, we invite you to contact your local office. The human NY-ESO-1-specific T Cell Receptor (TCR) lentiviruses (clone 1G4) are replication incompetent, HIV-based, VSV-G-pseudotyped lentiviral particles that are ready to infect almost all types of mammalian cells, including primary and non-dividing cells. These viruses transduce cells with a human TCR (clone 1G4) that specifically recognizes antigen NY-ESO-1 (New York esophageal squamous cell carcinoma 1), and in which the TCR α chain and β chain are linked by P2A. The lentiviruses also transduce a puromycin selection gene.<img style="display: block; margin-left: auto; margin-right: auto;" src="{{media url="wysiwyg/78675_description.png"}}" alt="" width="386" height="361" /> Figure 1. (A) Schematic of the lenti-vector used to generate the NY-ESO-1-specific TCR lentivirus and (B) Construct diagram showing expressed components of the NY-ESO-1-specific TCR. <br />TRAV and TRAC correspond to the

Please note this product may be subject to fees, we invite you to contact your local office. The human NY-ESO-1-specific T Cell Receptor (TCR) lentiviruses (clone 1G4) are replication incompetent, HIV-based, VSV-G-pseudotyped lentiviral particles that are ready to infect almost all types of mammalian cells, including primary and non-dividing cells. These viruses transduce cells with a human TCR (clone 1G4) that specifically recognizes antigen NY-ESO-1 (New York esophageal squamous cell carcinoma 1), and in which the TCR α chain and β chain are linked by P2A. The lentiviruses also transduce a puromycin selection gene.<img style="display: block; margin-left: auto; margin-right: auto;" src="{{media url="wysiwyg/78675_description.png"}}" alt="" width="386" height="361" /> Figure 1. (A) Schematic of the lenti-vector used to generate the NY-ESO-1-specific TCR lentivirus and (B) Construct diagram showing expressed components of the NY-ESO-1-specific TCR. <br />TRAV and TRAC correspond to the

Please note this product may be subject to fees, we invite you to contact your local office. The human NY-ESO-1-specific T Cell Receptor (TCR) lentiviruses (clone c259, also called α95:LY) are replication incompetent, HIV-based, VSV-G-pseudotyped lentiviral particles that are ready to infect almost all types of mammalian cells, including primary and non-dividing cells. These viruses transduce cells with a human TCR (clone c259) that specifically recognizes antigen NY-ESO-1 (New York esophageal squamous cell carcinoma 1), and in which the TCR α chain and β chain are linked by P2A. The lentiviruses also transduce a puromycin selection gene.  <img src="{{media url="wysiwyg/Imtx/78676.png"}}" alt="" width="500" height="440" /> Figure 1. (A) Schematic of the lenti-vector used to generate the NY-ESO-1-specific TCR lentivirus and (B) Construct diagram showing expressed components of the NY-ESO-1-specific TCR.<br />TRAV and TRAC correspond to the TCR alpha chain variable and constant regions

Please note this product may be subject to fees, we invite you to contact your local office. The human NY-ESO-1-specific T Cell Receptor (TCR) lentiviruses (clone c259, also called α95:LY) are replication incompetent, HIV-based, VSV-G-pseudotyped lentiviral particles that are ready to infect almost all types of mammalian cells, including primary and non-dividing cells. These viruses transduce cells with a human TCR (clone c259) that specifically recognizes antigen NY-ESO-1 (New York esophageal squamous cell carcinoma 1), and in which the TCR α chain and β chain are linked by P2A. The lentiviruses also transduce a puromycin selection gene.  <img src="{{media url="wysiwyg/Imtx/78676.png"}}" alt="" width="500" height="440" /> Figure 1. (A) Schematic of the lenti-vector used to generate the NY-ESO-1-specific TCR lentivirus and (B) Construct diagram showing expressed components of the NY-ESO-1-specific TCR.<br />TRAV and TRAC correspond to the TCR alpha chain variable and constant regions

Please note this product may be subject to fees, we invite you to contact your local office. The human MART-1-specific T Cell Receptor lentiviruses (clone DMF4) are replication incompetent, HIV-based, VSV-G-pseudotyped lentiviral particles that are ready to infect almost all types of mammalian cells, including primary and non-dividing cells. These viruses transduce a human TCR (clone DMF4) that specifically recognizes antigen MART-1 (Melanoma-associated antigen recognized by T cells-1, or Melan-A), and in which the TCR α chain and β chain are linked by P2A. The lentiviruses also transduce a puromycin selection gene.  <img src="{{media url="wysiwyg/78678.png"}}" alt="" width="450" height="374" /> Figure 1. (A) Schematic of the lenti-vector used to generate the MART-1-specific TCR lentivirus and (B) Construct diagram showing expressed components of the MART-1-specific TCR. TRAV and TRAC correspond to the TCR alpha chain variable and constant regions, respectively, whereas TRBV and TRBC

Please note this product may be subject to fees, we invite you to contact your local office. The human MART-1-specific T Cell Receptor lentiviruses (clone DMF4) are replication incompetent, HIV-based, VSV-G-pseudotyped lentiviral particles that are ready to infect almost all types of mammalian cells, including primary and non-dividing cells. These viruses transduce a human TCR (clone DMF4) that specifically recognizes antigen MART-1 (Melanoma-associated antigen recognized by T cells-1, or Melan-A), and in which the TCR α chain and β chain are linked by P2A. The lentiviruses also transduce a puromycin selection gene.  <img src="{{media url="wysiwyg/78678.png"}}" alt="" width="450" height="374" /> Figure 1. (A) Schematic of the lenti-vector used to generate the MART-1-specific TCR lentivirus and (B) Construct diagram showing expressed components of the MART-1-specific TCR. TRAV and TRAC correspond to the TCR alpha chain variable and constant regions, respectively, whereas TRBV and TRBC