Lentivirus

Please note this product may be subject to fees, we invite you to contact your local office. The human MART-1-specific T Cell Receptor lentiviruses (clone DMF5) are replication incompetent, HIV-based, VSV-G-pseudotyped lentiviral particles that are ready to infect almost all types of mammalian cells, including primary and non-dividing cells. These viruses transduce a human TCR (clone DMF5) that specifically recognizes antigen MART-1 (Melanoma-associated antigen recognized by T cells-1, or Melan-A), and in which the TCR α chain and β chain are linked by P2A. The lentiviruses also transduce a puromycin selection gene.  <img src="{{media url="wysiwyg/Imtx/78679.png"}}" alt="" width="450" height="397" /> Figure 1. (A) Schematic of the lenti-vector used to generate the MART-1-specific TCR lentivirus and (B) Construct diagram showing expressed components of the MART-1-specific TCR. TRAV and TRAC correspond to the TCR alpha chain variable and constant regions, respectively, whereas TRBV and

Please note this product may be subject to fees, we invite you to contact your local office. The human MART-1-specific T Cell Receptor lentiviruses (clone DMF5) are replication incompetent, HIV-based, VSV-G-pseudotyped lentiviral particles that are ready to infect almost all types of mammalian cells, including primary and non-dividing cells. These viruses transduce a human TCR (clone DMF5) that specifically recognizes antigen MART-1 (Melanoma-associated antigen recognized by T cells-1, or Melan-A), and in which the TCR α chain and β chain are linked by P2A. The lentiviruses also transduce a puromycin selection gene.  <img src="{{media url="wysiwyg/Imtx/78679.png"}}" alt="" width="450" height="397" /> Figure 1. (A) Schematic of the lenti-vector used to generate the MART-1-specific TCR lentivirus and (B) Construct diagram showing expressed components of the MART-1-specific TCR. TRAV and TRAC correspond to the TCR alpha chain variable and constant regions, respectively, whereas TRBV and

Please note this product may be subject to fees, we invite you to contact your local office. The Activator protein 1 (AP1) eGFP Reporter Lentiviruses are replication incompetent, HIV-based, VSV-G pseudotyped lentiviral particles that are ready to be transduced into almost all types of mammalian cells, including primary and non-dividing cells. The particles contain an eGFP gene driven by an AP1 response element located upstream of the minimal TATA promoter. After transduction, activation of the JNK signaling pathway and AP1-mediated activity in the target cells can be monitored by eGFP expression. <img src="{{media url="wysiwyg/Lentivirus/78680.png"}}" alt="" width="528" height="340" /> Figure 1. Schematic of the lenti-vector used to generate the AP1-eGFP Reporter Lentivirus.

The Anti-mesothelin CAR lentiviruses are replication incompetent, HIV-based, VSV-G-pseudotyped lentiviral particles that are ready to infect almost all types of mammalian cells, including primary and non-dividing cells. These viruses transduce the ScFv (single-chain fragment variable) of anti-mesothelin (Clone P4) linked to a 2^nd generation CAR (Chimeric Antigen Receptor) containing CD8 hinge and transmembrane domains, and the 4-1BB and CD3ζ signaling domains. A <img src="{{media url="wysiwyg/Imtx/78703_A.png"}}" alt="" width="372" height="297" /> B <img src="{{media url="wysiwyg/Imtx/78703_B.png"}}" alt="" width="390" height="100" /> Figure 1. (A) Schematic of the lenti-vector used to generate the anti-mesothelin CAR lentivirus and (B) Construct diagram showing components of the anti-mesothelin CAR.

Please note this product may be subject to fees, we invite you to contact your local office. The Firefly Luciferase Lentiviruses are replication incompetent, HIV-based, VSV-G pseudotyped lentiviral particles that are ready to infect almost all types of mammalian cells, including primary and non-dividing cells. The viruses transduce firefly luciferase under the control of an EF1A promoter. <img src="{{media url="wysiwyg/lentivirus_vectors/78740-G.png"}}" alt="" width="300" height="302" /> Figure 1. Schematic of the lenti-vector used to generate the Firefly Luciferase Lentivirus (Geneticin). <img src="{{media url="wysiwyg/lentivirus_vectors/78740-H.png"}}" alt="" width="300" height="295" /> Figure 1. Schematic of the lenti-vector used to generate the Firefly Luciferase Lentivirus (Hygromycin). <img src="{{media url="wysiwyg/lentivirus_vectors/78740-P.png"}}" alt="" width="300" height="305" /> Figure 1. Schematic of the lenti-vector used to generate the Firefly Luciferase Lentivirus

Please note this product may be subject to fees, we invite you to contact your local office. The Firefly Luciferase Lentiviruses are replication incompetent, HIV-based, VSV-G pseudotyped lentiviral particles that are ready to infect almost all types of mammalian cells, including primary and non-dividing cells. The viruses transduce firefly luciferase under the control of an EF1A promoter. <img src="{{media url="wysiwyg/lentivirus_vectors/78740-G.png"}}" alt="" width="300" height="302" /> Figure 1. Schematic of the lenti-vector used to generate the Firefly Luciferase Lentivirus (Geneticin). <img src="{{media url="wysiwyg/lentivirus_vectors/78740-H.png"}}" alt="" width="300" height="295" /> Figure 1. Schematic of the lenti-vector used to generate the Firefly Luciferase Lentivirus (Hygromycin). <img src="{{media url="wysiwyg/lentivirus_vectors/78740-P.png"}}" alt="" width="300" height="305" /> Figure 1. Schematic of the lenti-vector used to generate the Firefly Luciferase Lentivirus

Please note this product may be subject to fees, we invite you to contact your local office. The Firefly Luciferase Lentiviruses are replication incompetent, HIV-based, VSV-G pseudotyped lentiviral particles that are ready to infect almost all types of mammalian cells, including primary and non-dividing cells. The viruses transduce firefly luciferase under the control of an EF1A promoter. <img src="{{media url="wysiwyg/lentivirus_vectors/78740-G.png"}}" alt="" width="300" height="302" /> Figure 1. Schematic of the lenti-vector used to generate the Firefly Luciferase Lentivirus (Geneticin). <img src="{{media url="wysiwyg/lentivirus_vectors/78740-H.png"}}" alt="" width="300" height="295" /> Figure 1. Schematic of the lenti-vector used to generate the Firefly Luciferase Lentivirus (Hygromycin). <img src="{{media url="wysiwyg/lentivirus_vectors/78740-P.png"}}" alt="" width="300" height="305" /> Figure 1. Schematic of the lenti-vector used to generate the Firefly Luciferase Lentivirus

Please note this product may be subject to fees, we invite you to contact your local office. The Firefly Luciferase-eGFP Lentiviruses are replication incompetent, HIV-based, VSV-G pseudotyped lentiviral particles that are ready to infect almost all types of mammalian cells, including primary and non-dividing cells. These viruses transduce firefly luciferase and eGFP (Luc2-P2A-eGFP) driven by an EF1A promoter (Figure 1). The luciferase and eGFP proteins are co-expressed under the EF1A promoter in the cells, allowing greater flexibility for detection of the transduced cells.

Please note this product may be subject to fees, we invite you to contact your local office. The Firefly Luciferase-eGFP Lentiviruses are replication incompetent, HIV-based, VSV-G pseudotyped lentiviral particles that are ready to infect almost all types of mammalian cells, including primary and non-dividing cells. These viruses transduce firefly luciferase and eGFP (Luc2-P2A-eGFP) driven by an EF1A promoter (Figure 1). The luciferase and eGFP proteins are co-expressed under the EF1A promoter in the cells, allowing greater flexibility for detection of the transduced cells.