Lipids

PEG13-bis(Amino-Tri-(Acid-ethoxymethyl)-methane) is a hexafunctional PEG linker containing a pair of three carboxylic acids joined together by a PEG spacer. The carboxylic acids are free for coupling reactions with amines and alcohols. The long PEG spacer provides high aqueous solubility and alters DMPK.

BP Lipid 309 is an ionizable lipid analogue of ALC-0315 featuring a tertiary amine head, a central tertiary amine, and two identical esters linking to nonpolar tails. Ionizable lipids such as this may be applied in the development of lipid nanoparticles for drug delivery. Reagent grade, for research purpose. Please contact us for GMP-grade inquiries.

D-Lin-MC2-DMA is a synthetic ionizable lipid that is frequently used in combination with other lipids in the development of lipid nanoparticles for drug delivery.

D-Lin-MC4-DMA is a synthetic ionizable lipid that is frequently used in combination with other lipids in the development of lipid nanoparticles for drug delivery.

BP Lipid 310 is an ionizable aminolipid analog of CL1. The structure features an ethanolamine head and an ester linking to a polyunsaturated hydrophobic tail. This lipid may be used to encapsulate nucleic acids or small-molecule drugs to form lipid nanoparticles for drug delivery. Reagent grade, for research purpose. Please contact us for GMP-grade inquiries.

DOPE-PEG-DBCO, MW 2,000 is a PEG-lipid containing a DOPE and a DBCO group. DOPE is a phospholipid that is commonly employed in the development of lipid nanoparticles. DBCO is a click chemistry handle which is used to react with azides and form stable triazoles with target molecules.

16-(Azide-PEG6-ethylcarbamoyl)pentadecanoic-t-butyl ester is a hybrid PEG linker featuring an azide-PEG and an aliphatic t-butyl ester linked together at a central amide. Azides are click chemistry handle which are used to react with terminal alkynes or strained cyclooctynes while t-butyl esters can be hydrolyzed by strong acid to reveal a carboxylic acid.

benzyl N-[2-(prop-2-enamido)ethyl]carbamate is a short aliphatic linker featuring a Cbz-protected amine and an acrylamide. Acrylamide is a Michael acceptor which is a good Michael acceptor which can be used in thiol-based bioconjugation or polymerization. Meanwhile, the Cbz protecting group can be removed using Pd-C hydrogenation to reveal a free amine that can participate in a wide variety of reactions such as couplings or reductive amination.

16-(Amine-PEG6-ethylcarbamoyl)pentadecanoic-t-butyl ester is a PEG lipid