Lipids

3-[4,4-Bis(octyloxy)-1-oxobutoxy]-2-(hydroxymethyl)propyl (9Z)-9-hexadecenoate is a lipid molecule featuring a primary alcohol, a palmitoleic acid, and a butanoic acid linked to two C8 chains via an acetal. Compounds such as this may also be used as intermediates in building lipids for use in lipid nanoparticles.

BP Lipid 313 is an ionizable lipid analogue of ALC-0315 featuring an ethanolamine head and two carbamate tails, one being an undecyl tail and the other being a branched C17. Ionizable lipids such as this may be applied in the development of lipid nanoparticles for drug delivery. Reagent grade, for research purpose. Please contact us for GMP-grade inquiries.

t-Boc-N-amido-PEG4-Val-Cit is a protease-cleavable ADC linker featuring a Boc-protected amine, a hydrophilic PEG spacer, and a Val-Cit dipeptide. The Val-Cit dipeptide is cleavable by cell proteases and features a carboxylic acid which is free for coupling reactions with amines to form amides. The Boc can be removed under acidic conditions to reveal a free primary amine, which may be used in a variety of reactions such as coupling or reductive amination.

This reagent is a modified lipid containing an omega-terminal alkyne. The terminal alkyne group can be used in a highly specific linking reaction with azide-containing reagents, known as click chemistry, in the presence of a copper (Cu)-containing catalyst. Alkyne cholesterol represents a versatile, sensitive, and easy-to-use tool for tracking cellular cholesterol metabolism and localization as it allows for manifold detection methods including mass spectrometry, and fluorescence microscopy.

This reagent is a modified lipid containing an omega-terminal alkyne. The terminal alkyne group can be used in a highly specific linking reaction with azide-containing reagents, known as click chemistry, in the presence of a copper-containing catalyst. Alkyne cholesterol represents a versatile, sensitive, and easy-to-use tool for tracking cellular cholesterol metabolism and localization as it allows for manifold detection methods including mass spectrometry, and fluorescence microscopy.

This reagent is a modified lipid containing an omega-terminal alkyne. The terminal alkyne group can be used in a highly specific linking reaction with azide-containing reagents, known as click chemistry, in the presence of a copper (Cu)-containing catalyst. E-Cholesterol Alkyne (19-ethynylcholesterol) represents a versatile, sensitive, and easy-to-use tool for tracking cellular cholesterol metabolism and localization as it allows for manifold detection methods including mass spectrometry, and fluorescence microscopy.

2-(7Z,10Z)-7,10-Hexadecadien-1-yloxirane is an intermediate for the preparation of lipid molecules. It features a polyunsaturated chain with an epoxy ring that can be opened by nucleophiles.

Azido-PEG8-diglycoamide-Lys(Boc)-PAB is a PEG labeling reagent featuring an azide, a Val-Lys dipeptide, and a PAB group. Azides are highly reactive in click chemistry with terminal alkynes and strained cyclooctynes while the Val-Lys dipeptide is enzyme cleavable and triggers payload release via an elimination mechanism within the PAB structure. Finally, the ε-amine of the lysine is Boc-protected.

Azido-PEG8-triethoxysilane is a short PEG linker featuring an azide, which is used in click chemistry with alkynes, and a triethoxysilane group, which may be used to retain a compound on silica surfaces such as those used in normal phase chromatography.