Lipids

Docosanoic acid, also known as behenic acid, is a saturated fatty acid that consists of a 22-carbon aliphatic chain ending in a carboxylic acid group.

Tricosanoic acid, also known as tricosylic acid, is a 23-carbon long-chain saturated fatty acid, and it occurs naturally in the leaves of Cecropia adenopus and in various other plants.

Tetracosanoic acid, also known as lignoceric acid, is a 24-carbon saturated fatty acid that features a long aliphatic chain ending in a carboxylic acid group.

Azide-PEG8-Amido-tri-(carboxyethoxymethyl)-methane is a multifunctional reagent combining an azide group and three carboxylic acids. The azide group is reactive towards terminal alkynes or strained cyclooctynes such as DBCO and BCN. The carboxylic acids can react with primary amines or other nucleophiles to form stable amide bonds. Finally, the PEG spacer and amide bonds provide aqueous solubility to this molecule.

BP Lipid 321 is an ionizable aminolipid analog of CL1 which features a unique 3-hydroxyazetidine head and an ester linking to a polyunsaturated hydrophobic tail. Ionizable lipids such as this may be applied in the development of lipid nanoparticles for drug delivery. Reagent grade, for research purpose. Please contact us for GMP-grade inquiries.

BP Lipid 322 is a multichargeable lipid analog of CL1 which features a novel 2-hydroxyethyl piperazine ionizable head and an ester linking to a polyunsaturated hydrophobic tail. Ionizable lipids such as this may be applied in the development of lipid nanoparticles for drug delivery. Reagent grade, for research purpose. Please contact us for GMP-grade inquiries.

Boc-Gly-Gly-Gly-PEG-methyltetrazine is a PEG linker featuring a methyltetrazine and a glycine tripeptide featuring a Boc-protected N-terminus. Methyltetrazine is a click chemistry handles that can react with TCO groups while the Boc protecting group can be removed to reveal a primary amine.

Mal-amide-PEG8-Val-Cit-PAB-PNP is a cleavable ADC linker featuring a maleimide, a PEG spacer, a Val-Cit dipeptide, a PAB. and a PNP carbonate. Maleimide is a thiol-specific covalent linker which is used to label cysteine residues in proteins while the PNP group acts as a highly activated leaving group. Val-Cit linkers are cleaved by cytoplasmic peptidases.

BP Lipid 323 is an ionizable aminolipid analog of CL1 which features a unique azetidine head and an ester linking to a polyunsaturated hydrophobic tail. Ionizable lipids such as this may be applied in the development of lipid nanoparticles for drug delivery. Reagent grade, for research purpose. Please contact us for GMP-grade inquiries.