Lipids

2-(bromomethyl)-1,2,3-(9Z)-trioctadeca-9-enoate is a chemical reagent featuring a bromide and three identical esters coupled to unsaturated C18 tails. Bromide is easily displaced by nucleophiles in substitution reactions. Compounds such as this may be used as intermediates in building lipids for use in lipid nanoparticles.

3,6-Bis(4-aminobutyl)-2,5-piperazinedione

2-(bromomethyl)-2-(hydroxymethyl)propane-1,3-(9Z)-dioctadeca-9-dienoate is a chemical reagent featuring a bromide, a primary alcohol, and two identical esters coupled to unsaturated C18 tails. Bromide is easily displaced by nucleophiles in substitution reactions, while alcohols may be used in a wide variety of reactions. Compounds such as this may be used as intermediates in building lipids for use in lipid nanoparticles.

Lipid 10 is an ionizable lipid which may be used to develop lipid nanoparticles in drug discovery. The structure features a methylpiperazine head, a central tertiary amine, and two identical polyunsaturated C20 tails. The prescence of three amines in this structures allows it to carry up to three positive charges depending on pH. Ionizable lipids such as this may be applied in the development of lipid nanoparticles for drug delivery.

BP Lipid 317 is an amino lipid featuring a dimethylamine headgroup connected to two oleic esters and a hydroxy group which may be used for further derivatization. Ionizable lipids such as this may be applied in the development of lipid nanoparticles for drug delivery. Reagent grade, for research purpose. Please contact us for GMP-grade inquiries.

BP Lipid 318 is a lipid analog comprised of three unsaturated fatty acid tails and an ionizable dimethylamino butanoate head group. This lipid may be used in the generation of lipid nanoparticles (LNPs) for mRNA delivery. Reagent grade, for research purpose. Please contact us for GMP-grade inquiries.

DOPE-PEG-Fluor 647, MW 2,000 is a PEG-lipid-dye conjugate with a DOPE phospholipid and a Fluor 647 cyanine dye joined together by a large PEG spacer. DOPE is an unsaturated phospholipid featured in the construction of lipid nanoparticles while Fluor 647 is a fluorescent dye that may be used in fluorescence microscopy among other in vivo applications.

DGTS (1,2-dipalmitoyl-sn-glycero-3-O-4'-[N,N,N-trimethyl]-homoserine) is a helper lipid that is structurally similar to DSPE or DOPE, but features a butanoate and a quaternary ammonium salt. Cationic lipids such as these are often used in lipid nanoparticle development.

Beta-Sitosterol, a prominent plant phytosterol, shares similarities with cholesterol, as it can undergo oxidation, forming beta-sitosterol oxides. As a C-24 alkyl derivative, its tail and body variations impact size, mRNA encapsulation efficiency (EE), and transfection efficiency of lipid nanoparticles (LNPs). Consequently, it shows promise in improving gene transfection capabilities.