Lipids

TT3 is a multi-ionizable lipid featuring three amine-branched aliphatic C12 chains linked at a central phenyl ring by amide bonds. Ionizable lipids such as this may be applied in the development of lipid nanoparticles for drug delivery.

Lipid A6 is an ionizable amino lipid featuring a dimethyl headgroup linked by an ester to a central branched linker featuring two unsaturated esters with internal alkynes. Its structure is similar to D-Lin-MC3-DMA, however it has shown a significantly improved ability in cell transfection over the respective MC3/C12-200/cKK-E12 LNPs.

G0-C14 is an ionizable amino lipid that is frequently involved in the preparation of lipid nanoparticles for nucleic acid delivery.

304-O13 exhibits comparable potency to the non-degradable C12-200 standard while displaying significantly reduced toxicity at high doses. It's important to mention that ester-containing ionizable lipids usually show lower effectiveness compared to non-degradable counterparts due to rapid hydrolysis hindering efficient delivery.

Amine-PEG8-Amido-tri-(carboxyethoxymethyl)-methane, HCl salt is a tetrafunctional PEG linker including three terminal caboxyl groups, which can react with primary amine groups in the presence of activators such as HATU, and terminal amine for coupling with an NHS ester to form an amide bond. The PEG8 linker improves the hydrophilicity of the compound.

BP Lipid 324 is a morpholine-functionalized lipid comprised of three oleic acid tails and a head group five carbon atoms in length. This lipid may be used in the generation of lipid nanoparticles (LNPs) for drug delivery. Reagent grade, for research purpose. Please contact us for GMP-grade inquiries.

BP Lipid 325 is an amino lipid comprised of three oleic fatty acid tails and an ionizable N,N-dimethylamine head group five carbon atoms in length. This lipid may be used in mRNA and drug delivery applications. Reagent grade, for research purpose. Please contact us for GMP-grade inquiries.

Hydroxy-PEG-t-butyl ester, MW 2,000

BP Lipid 326 is a novel amino lipid comprised of three unsaturated fatty acid tails and an ionizable piperidine head group five carbon atoms in length. This lipid may be used in the generation of lipid nanoparticles (LNPs) for mRNA delivery. Reagent grade, for research purpose. Please contact us for GMP-grade inquiries.