Lipids

BP Lipid 369 is a novel amino lipid which features a unique 3-hydroxyazetidine head group with an ester linkage to two adipate ester branched tails. This lipid may be used in the formulation of lipid nanoparticles for drug or mRNA delivery. Reagent grade, for research purpose. Please contact us for GMP-grade inquiries.

BP Lipid 371 is an ionizable lipid comprised of three oleic acid tails and a unique morpholinyl propionate head group. This lipid may be used in the generation of lipid nanoparticles (LNPs) for mRNA delivery. Reagent grade, for research purpose. Please contact us for GMP-grade inquiries.

endo-BCN-PEG2-Val-Cit-PAB-MMAE is a synthetic linker-payload which may be applied for the creation of antibody drug conjugates (ADCs). It contains a chemically labile Val-Cit dipeptide and a MMAE payload. The MMAE is a synthetic antineoplastic agent that can be attached to a monoclonal antibody (mAb). The BCN group reacts with azide-tagged compounds or biomolecules.

BP Lipid 372 is a multichargeable amino lipid which features unsaturated lipid tails and a PEG4 linkage to enhance water solubility and biocompatibility. This lipid may be used in the generation of lipid nanoparticles (LNPs) for mRNA or drug delivery. Reagent grade, for research purpose. Please contact us for GMP-grade inquiries.

BP Lipid 373 is a multichargeable lipid which features unsaturated lipid tails and a PEG2 linkage to enhance water solubility. This lipid may be used in the generation of lipid nanoparticles (LNPs) for mRNA delivery. Reagent grade, for research purpose. Please contact us for GMP-grade inquiries.

CL4H6, an ionizable cationic amino lipid with an apparent pKa of 6.35, has been utilized in creating lipid nanoparticles (LNPs). LNPs incorporating CL4H6 and carrying siRNA for Factor VII reduction in mice's liver levels and tumor-targeting siRNAs for CD45, STAT3, and HIF-1alpha in OS-RC-2 renal cancer mouse xenograft models demonstrate tumor volume reduction.

C14-4, an ionizable cationic lipid with a pKa of 6.5, has been employed in lipid nanoparticles (LNPs) for mRNA delivery. These LNPs, containing C14-4 and mRNA encoding a chimeric antigen receptor (CAR), effectively induce CAR expression in human T cells ex vivo, comparable to electroporation but with less toxicity. Additionally, they exhibit cytotoxicity against Nalm-6 leukemia cells in vitro. The pKa is 6.51.

A18-Iso5-2DC18 is an unsaturated ionizable lipid derived from alkylene ketones, can effectively transport mRNA vaccines and trigger the stimulator of interferon genes (STING) pathway for enhanced immune response.

306-N16B is an ionizable lipid that efficiently transports mRNA within lipid nanoparticles (LNPs) to the mouse lung in vivo. Conversely, 306-O12B is designed for targeted mRNA delivery to the mouse liver in vivo.