Lipids

Lipid CP-LC-1073 is an ionizable cationic amino lipid derived from homocysteine, a naturally occurring amino acid. This lipid has demonstrated an efficient delivery and high protein expression of different kinds of RNA (mRNA, cRNA and saRNA) in vivo. Moreover, using a typical LNP formulation (IL/Ch/DOPE/PEG: 50/38.5/10/1.5), it has shown to induce specific lung targeting much more efficiently that other commercial alternatives through IV injection, with no signs of toxicity.

Lipid CP-LC-1405 is an ionizable cationic amino lipid derived from homocysteine, a naturally occurring amino acid. This lipid has demonstrated an efficient delivery and high protein expression of different kinds of RNA (mRNA, cRNA and saRNA) in vivo, with no signs of toxicity.

Lipid CP-LC-1406 is an ionizable cationic amino lipid derived from homocysteine, a naturally occurring amino acid. This lipid has demonstrated an efficient delivery and high protein expression of different kinds of RNA (mRNA, cRNA and saRNA) in vivo, with no signs of toxicity.

Lipid CP-LC-1447 is an ionizable cationic amino lipid derived from homocysteine, a naturally occurring amino acid. This lipid has demonstrated an efficient delivery and high protein expression of different kinds of RNA (mRNA, cRNA and saRNA) in vivo. Moreover, using a typical LNP formulation (IL/Ch/DOPE/PEG: 50/38.5/10/1.5), it has shown to induce specific spleen targeting much more efficiently that other commercial alternatives through IV injection, with no signs of toxicity.

Propargyl-PEG-acid, MW 2,000 constitutes a polyPEG linker with a 2k PEG polymer for enhanced hydrophilicity and propargyl group that can participate in copper catalyzed azide-alkyne Click Chemistry. Reagent grade, for research purpose. Please contact us for GMP-grade inquiries.

DBCO-PEG4-tri-(carboxyethoxymethyl)-methane constitutes a branched PEG linker that includes DBCO for copper-free click reactions and three terminal carboxyl groups for reacting with primary amines in the presence of activators like HATU. The PEG linkers bolster the hydrophilicity of the molecule. Reagent grade, for research purpose. Please contact us for GMP-grade inquiries.

Cholesterol-PEG4-DBCO constitutes a PEG lipid containing cholesterol, which aids in targeting drugs to membranes and is crucial in lipid nanoparticles for modern drug and vaccine delivery, and DBCO, which serves as a click chemistry handle for reacting with azides without copper. The PEG arm enhances the water-solubility of the molecule.

MIC1/Lipid C2 is an ionizable lipid for forming lipid nanoparticles (LNPs). Targeting EBV-protein with mRNA vaccines is a promising way to treat EBV-related tumors. MIC1 LNPs can be used as vehicle to deliver mRNA vaccine to tumor-draining lymph nodes. This LNP exhibited high transfection efficiency and lysosomal escape ability.  This ionized lipid may have wide applications in immunotherapy in EBV-related tumors.

LP-01 (CIN-16645) is an ionizable cationic lipid and has similar structure as 11-A-M (Echelon Cat#: N-1111). LP-01 can form lipid nanoparticles (LNPs) with cholesterol DSPC and PEG2k-DMG. The LNP nucleic acid assemblies can deliver single-guide RNA (sgRNA) targeting MHC class II transactivator (CIITA) in T cells.