Lipids

m-PEG12-amido-PEG24-DSPE serves as a polyPEG compound conjugated with DSPE. The DSPE-PEGs have been FDA approved for medical applications. The hydrophobic properties of the DSPE allow for the encapsulation and congregation of other hydrophobic drugs. The hydrophilic PEG linkers improve the water solubility of the overall compound allowing for the delivery of the drug.

MAL-PEG24-amido-PEG24-TFP ester functions as a long heterobifunctional PEG linker featuring a terminal thiol-reactive maleimide group and TFP ester, which can react with primary amine groups and is less susceptible to undergo hydrolysis compared to NHS ester. The PEG chain elevates the hydrophilicity of the compound and helps fine-tune DMPK properties.

m-PEG25-DSPE represents a polyPEG reagent conjugated with DSPE, approved by the FDA for medical applications. The hydrophobic DSPE encapsulates hydrophobic drugs, while the hydrophilic PEG linkers enhance water solubility for effective drug delivery.

DBCO-PEG24-amido-PEG24-DSPE represents a polyPEG lipid with a terminal DBCO group that reacts azides via copper-free catalyzed click chemistry and DSPE, which is approved by the FDA for medical applications. The hydrophobic DSPE encapsulates hydrophobic drugs, while the hydrophilic PEG linkers increase water solubility for effective drug delivery.

DOTA-tris(acid)-amido-PEG24-amido-PEG24-DSPE consists of DSPE attached via hydrophilic PEG polymers to DOTA, which is used as a chelating agent for cations. The hydrophobic DSPE encapsulates hydrophobic drugs, while the hydrophilic PEG chains enhance water solubility for effective drug delivery.

Carboxyfluorescein-dPEG24-amido-dPEG24-DSPE is comprised of DSPE connected to a fluorescein, which is a universal dye applied in dye labeling. DSPE encapsulates hydrophobic drugs, while the hydrophilic PEG linkers enhance water solubility, facilitating effective drug delivery.

Biotin-PEG 4-amido-PEG24-amido-PEG24-DSPE serves as a biotinylated lipid where the hydrophobic DSPE encapsulates hydrophobic drugs, and the hydrophilic PEG linkers enhance water solubility, facilitating effective drug delivery.

DSG-PEG-DBCO, MW 3,400 represents a unique PEG lipid featuring DSG connected to a DBCO moiety via a water-soluble 3.4k polymer PEG linkage. The DBCO group can be used for copper-free Click Chemistry reactions. It is used for liposome preparation. DSG-PEG has become known for lipid nanoparticle (LNP) preparation for small interfering RNA (siRNA) delivery research. The water-soluble polyPEG aids in drug delivery.

A fully saturated ketone lipid featuring two biodegradable ester linkages to branched lipid tails. Reagent grade, for research purpose. Please contact us for GMP-grade inquiries.