Lipids

DSPE-Carbamate-PEG-Maleimide, MW 2,000 constitutes a PEG lipid with DSPE attached to a 2k PEG polymer chain and a terminal maleimide, which will react with a thiol group to form a covalent bond, enabling the connection of biomolecule with a thiol. The PEG chain enhances the water-solubility of the molecule.

BP Lipid 434 is a multichargeable lipid featuring saturated branched tails, two biodegradable ester linkages, and an methoxyPEG3-amide branch adjacent to the polar head group. This compound may be used in the formulation of lipid nanoparticles (LNP's) for delivery applications. Reagent grade, for research purpose. Please contact us for GMP-grade inquiries.

3,5-bis(2-methylheptanoate)-benzaldehyde

Azido-PEG1-Val-Cit-PAB-PNP constitutes a cleavable ADC linker used in antibody-drug conjugates (ADCs). The Val-Cit linker was designed to be cleaved by cathepsin B. The PNP group is a good leaving group when reacting with amine-bearing payloads. Additionally, the azido group reacts with DBCO, BCN, or linear alkyne groups via click chemistry. The PEG unit enhances the water-solubility of the molecule.

Lipid CAD9 is a multichargeable cationionc lipioid featuring a piperazine core and biodegradable aldehyde-based tails. Lipid CA9 has been identified as an effective component of lipid nanoparticle formulations for targeted mRNA delivery (Nat Commun 2024, 15, 1884). Reagent grade, for research purpose. Please contact us for GMP-grade inquiries.

A triacylglyceride analog featuring two 15-methyl palmitic acid tails and one unsaturaed linoleic acid tail. Introduction of the iso- methyl branched fatty acids has been carefully desgined to investigate the effect on self-assembly properties, solubilization of other lipids, and membrane fluidity. Reagent grade, for research purpose. Please contact us for GMP-grade.

PC Mal-PEG4-NHS carbonate ester represents a photocleavable linker with a terminal maleimide that can react with thiol or cysteine to generate a thiosuccinimide molecule which is commonly used for bioconjugation. NHS carbonate ester labels the primary amines (-NH2) of proteins, amine-modified oligonucleotides, and other amine-containing molecules. The PEG spacer imparts hydrophilicity. This structure allows for efficient photorelease of linked molecules, typically achieving over 90% cleavage in 5-25 minutes using a near-UV lamp.

BP Lipid 437 is a branched multichargeable lipid featuring a piperazine core with amide linkage to asymmetric aliphatic tails. This compound may be used in the formulation of lipid nanoparticles (LNP's) for mRNA delivery applications. Reagent grade, for research purpose. Please contact us for GMP-grade inquiries.

BP Lipid 438 is a mutichargeable lipid featuring a piperazine core, symmetric aliphatic amine spacers, and amide linkages to two fatty tails. This compound may be used in the formulation of lipid nanoparticles (LNP's) for mRNA or drug delivery applications. Reagent grade, for research purpose. Please contact us for GMP-grade inquiries.