Lipids

This 15 carbon long photoactivatable and clickable fatty acid may be used for a global analysis of protein–lipid interactions in living cells.

It is a synthetic phospholipid that has been shown to promote apoptosis in cells. It binds to the mitochondrial membrane, oligomerizes, and disrupts the membrane by forming pores that allow for passage of cytochrome c and other molecules. It also has been shown to have antimicrobial properties that are related to its ability to cause death of bacteria. The acyl chains of this lipid stimulate the production of reactive oxygen species and can cause DNA damage and lipid peroxidation. It is a symmetrical molecule with two identical acyl chains, which form a double-helical structure when bound together.

Arachidonic acid alkyne is a form of arachidonic acid with an ω-terminal alkyne. The terminal alkyne group can be used in click chemistry linking reactions to tag arachidonic acid with fluorescent or biotinylated labels for analysis of its metabolism and biological activity. Because the alkyne group is at the ω-terminus, this compound can be used to easily tag metabolites and derivatives.

Oleic acid alkyne is a form of oleic acid with an ω-terminal alkyne. The terminal alkyne group can be used in click chemistry linking reactions, to tag oleic acid with fluorescent or biotinylated labels for analysis of its metabolism and biological activity.

It is an antibody that recognizes the carboxyl-terminal sequence of the PC protein. It is a research tool that can be used in cell biology and peptide pharmacology. The 16:0(Alkyne)-18:1 pc antibody has been shown to activate ion channels, which may be due to its ability to bind and inhibit phosphorylation of the C-terminus of the PC protein.

It is a cationic lipid with high purity and excellent solubility in water. 16:0(Alkyne)-18:1 pe has been shown to activate ion channels, as well as inhibit ligand binding to receptors. It has also been used as a research tool for studying protein interactions, such as the study of peptides and antibodies. 16:0(Alkyne)-18:1 pe is an excellent candidate for use in pharmacology.

Photoclick sphingosine is a photoreactive probe for the study of sphingosine metabolism. It contains a terminal clickable alkyne moiety and a photoactivatable diazirine group that allow its interaction with sphingosine binding proteins and photo-activated cross-linking of its interacting partners, respectively. Photoclick sphingosine has been used to monitor the metabolism of sphingosine and visualize protein-lipid interaction complexes in S1PL-/- mouse embryonic fibroblasts (MEFs).