Lipids

Inositol phosphates are important signaling molecules involved in numerous cellular functions. Inositol 1 3 4-trisphosphate (Ins(1 3 4)P3) is an intermediate in the inositol phosphate pathway. Ins(1 3 4)P3 inhibits Ins(3 4 5 6)P4 1-kinase which regulates Ins(3 4 5 6)P4 levels. Ins(3 4 5 6)P4 in turn is responsible for inhibiting calcium-activated chloride channels. Ins(1 3 4)P3 is produced by dephosphorylation of Ins(1 3 4 5)P4 by a 5-phosphatase. Ins(1 3 4)P3 is a substrate for phosphatases yielding Ins(1 3)P2 and Ins(3 4)P2. Powered by Bioz See more details on Bioz

Inositol phosphates are important signaling molecules involved in numerous cellular functions. Inositol 1 3 5-trisphosphate (Ins(1 3 5)P3) is not an intermediate in the inositol phosphate pathway but corresponds to the PtdIns(3 5)P2 headgroup. Powered by Bioz See more details on Bioz

Inositol phosphates are important signaling molecules involved in numerous cellular functions. Inositol 1 4 5-trisphosphate (Ins(1 4 5)P3) aka IP3 is a second messenger produced by phospholipase C catalyzed hydrolysis of phosphatidylinositol 4 5-bisphosphate (PIP2). IP3 binds to the IP3-receptor on the endoplasmic reticulum causing calcium to be released through the opening of a tetrameric ion channel. IP3 is rapidly metabolized by a specific series of inositol phosphatases and kinases. Powered by Bioz See more details on Bioz

Inositol phosphates are important signaling molecules involved in numerous cellular functions. Inositol 1 3 4 5-tetrakisphosphate (Ins(1 3 4 5)P4) aka IP4 is produced from Ins(1 4 5)P3 in stimulated cells by IP3 3-kinase (Itpkb). IP4 acts in conjunction with IP3 to mobilize intracellular calcium. In addition IP4 has roles in T cell precursor development and responsiveness and thymocyte reactivity to antigens. Powered by Bioz See more details on Bioz

Inositol phosphates are important signaling molecules involved in numerous cellular functions. Inositol 1 3 4 6-tetrakissphosphate (Ins(1 3 4 6)P4) is an intermediate in the synthesis of InsP6 (phytic acid) being phosphorylated by Ins(1 3 4 6)P4 5-kinase to Ins(1 3 4 5 6)P5. It is formed from Ins(1 3 4)P3 by Ins(1 3 4)P3 5 6-kinase.

Inositol phosphates are important signaling molecules involved in numerous cellular functions. This Inositol 1 3 4 5-tetrakisphosphate (Ins(1 3 4 5)P4) analog is labeled with biotin through a three-carbon linker at the 1-position on the inositol ring. Ins(1 3 4 5)P4 Biotin can be bound to streptavidin coated surfaces.

Inositol phosphates are important signaling molecules involved in numerous cellular functions. This Inositol 1 4 5-trisphosphate (Ins(1 4 5)P3) analog is labeled with biotin through a three-carbon linker at the 1-position on the inositol ring. Ins(1 4 5)P3 Biotin can be bound to streptavidin coated surfaces. Powered by Bioz See more details on BiozKeywords: D-myo-Inositol 1 4 5-trisphosphate biotin biotin-Ins(1 4 5)P3 biotin-I(1 4 5)P3 or biotin-IP3

Lipid coated beads are designed for use in protein pull-down experiments. Use to test for lipid binding of purified protein proteins in cell lysate or binding of radiolabeled in vitro translation products.Ins(1 3 4 5)P4 Beads are composed of agarose with 10 nanomoles of bound Ins(1 3 4 5)P4 per mL of beads enough for several protein binding experiments. Each 1 mL order of Ins(1 3 4 5)P4 Beads includes a small amount of control beads. Larger quantities of Control Beads are also available for purchase.<Storage4 °C - do not freeze

**This product is being discontinued but stock is currently available.  Please call to place order: 801-588-0455**Membrane permeant inositol polyphosphates are employed in cell signaling experiments to introduce exogenous inositol polyphosphates across cell membranes. Some examples of applications are listed below. See the following page for an example protocol.1) M. Vajanaphanich et al. “Long-term uncoupling of chloride secretion from intracellular calcium levels by Ins(3 4 5 6)P4” Nature 1994 971 711-714.2) M.T. Rudolf et al. ”A membrane-permeant bioactivatable derivative of Ins(1 3 4)P3 and its effect on Cl(-)-secretion from T84 cells” Bioorg. Med. Chem.Lett. 1998 8 1857-1860.3) X. Yang et al. “Inositol 1 3 4-trisphosphate acts in vivo as a specific regulator of cellular signaling by inositol 3 4 5 6-tetrakisphosphate.” J. Biol. Chem. 1999 274 18973-18980.