Lipids

16-(Azide-PEG6-ethylcarbamoyl)pentadecanoic-t-butyl ester is a hybrid PEG linker featuring an azide-PEG and an aliphatic t-butyl ester linked together at a central amide. Azides are click chemistry handle which are used to react with terminal alkynes or strained cyclooctynes while t-butyl esters can be hydrolyzed by strong acid to reveal a carboxylic acid.

benzyl N-[2-(prop-2-enamido)ethyl]carbamate is a short aliphatic linker featuring a Cbz-protected amine and an acrylamide. Acrylamide is a Michael acceptor which is a good Michael acceptor which can be used in thiol-based bioconjugation or polymerization. Meanwhile, the Cbz protecting group can be removed using Pd-C hydrogenation to reveal a free amine that can participate in a wide variety of reactions such as couplings or reductive amination.

16-(Amine-PEG6-ethylcarbamoyl)pentadecanoic-t-butyl ester is a PEG lipid

16-(Bromoacetamido-PEG6-ethylcarbamoyl)pentadecanoic-t-butyl ester is a PEG linker featuring a bromoacetamide and a terminal t-butyl ester. Bromoacetamide is a thiol-specific covalent ligand which can be used in labeling proteins via their cysteine residues, while the t-butyl ester can be hydrolyzed to reveal a carboxylic acid that can be used to couple with amines or alcohols.

DSPE-PEG-DBCO, MW 2,000 is a PEG lipid conjugate featuring a DSPE phospholipid and a DBCO group. DSPE is a saturated phospholipid that is commonly used to prepare lipid nanoparticles in drug delivery, while DBCO is a click chemistry handle that is frequently used to conjugate with azides on target molecules to form stable triazole linkages.

MC-Val-Cit-PAB-SN38 is a cleavable ADC linker featuring a maleimide, a Val-Cit dipeptide, a PAB group and an SN38 warhead. Maleimide is a covalent ligand used for linking thiols such as those in cysteines residues in proteins, while the Val-Cit-PAB motif is an enzyme-cleavable linker. This linker efficiently releases the toxin, SN38, to target cells to cause cellular apoptosis.

BP Lipid 311 is a branched amino lipid featuring a dimethylamino headgroup, esters of a palmitoleic acid group and an aliphatic acetal. Ionizable lipids such as this may be applied in the development of lipid nanoparticles for drug delivery. Reagent grade, for research purpose. Please contact us for GMP-grade inquiries.

Desthiobiotin-PEG3-Amine is a short PEG linker featuring a primary amine and a desthiobiotin group. Primary amines readily form amides with carboxylic acids in the presence of coupling reagents such as HATU or EDC. Desthiobiotin is used for affinity-based applications such as pull-down assays or for ligating with streptavidin proteins.

JQ1 carboxylic acid serves as a potent BET bromodomain inhibitor. It features a carboxylic acid functional group, making it suitable for conjugation reactions.