Lipids

Lipid 10 is an ionizable lipid which efficiently delivers siRNA into leukocytes.

TT3 together with helper lipid DMG-PEG2000 Cholesterol and mRNA formed TT3 lipid nanoparticles (LNPs) which improve the delivery efficiency of firefly luciferase FLuc mRNA over 350-fold in vitro. TT3 LNPs with human factor IX (hFIX) mRNA can efficiently improve the hFIX level to normal physiological values in FIX-knockout mice.

306-O12B is an ionizable biodegradable lipid used to generate lipid nanoparticles (LNPs) for delivery of RNA. The 306-O12B LNP delivery system was more efficient than MC-3 LNP delivery system in liver-targeted delivery of nucleic acids.

93-O17O is an ionizable lipid used in lipid nanoparticles(LNPs). LNP compositions have proven effective as transport vehicles into cells and/or intracellular compartments for biologically active substances such as small molecule drugs proteins and nucleic acids.

306-N16B is an ionizable lipid which is capable of selectively delivering mRNA in lipid nanoparticles (LNPs) to the mouse lung in vivo while 306-O12B (Echelon Cat# N-1128) can selectively delivery mRNA to the mouse liver in vivo.

Stearic acid is a long chain dietary saturated fatty acid which exists in many animal and vegetable fats and oils.

Nonadecanoic Acid is a saturated fatty acid with a 19-carbon chain and a terminal carboxylic acid group. It’s a long-chain fatty acid.

Arachidic acid is a saturated fatty acid with a 20-carbon chain and a terminal carboxyl group (COOH).

Heneicosanoic acid, also known as heneicosylic acid, is a straight-chain 21-carbon saturated fatty acid