Lipids

Mes-PEG2-CH2-t-butyl ester is a PEG linker consisting of a PEG2 linker for improved water-solubility of the compound and a t-butyl ester group which can be deprotected under acidic conditions. The mesylate serves as an excellent leaving group, offering all the advantages without the limitation of having an acidic proton that could react with nucleophiles.

2-(bromomethyl)-2-(hydroxymethyl)propane-1,3-(9Z,12Z)-dioctadeca-9,12-dienoate is a chemical reagent featuring a bromide, a primary alcohol, and two identical esters coupled to unsaturated C18 tails. Bromide is easily displaced by nucleophiles in substitution reactions, while alcohols may be used in a wide variety of reactions. Compounds such as this may be used as intermediates in building lipids for use in lipid nanoparticles.

DOPE-PEG-Cy5.5, MW 5,000 is a PEG-lipid-dye conjugate featuring a DOPE phospholipid and a Cy5.5 dye. DOPE is featured prominently in lipid nanoparticles for its ability to readily form micelles while Cy5.5 is a fluorescent dye which is used in histology, FRET and other fluorescence-based assays in vivo.

2-(bromomethyl)-1,2,3-(9Z)-trioctadeca-9-enoate is a chemical reagent featuring a bromide and three identical esters coupled to unsaturated C18 tails. Bromide is easily displaced by nucleophiles in substitution reactions. Compounds such as this may be used as intermediates in building lipids for use in lipid nanoparticles.

3,6-Bis(4-aminobutyl)-2,5-piperazinedione

2-(bromomethyl)-2-(hydroxymethyl)propane-1,3-(9Z)-dioctadeca-9-dienoate is a chemical reagent featuring a bromide, a primary alcohol, and two identical esters coupled to unsaturated C18 tails. Bromide is easily displaced by nucleophiles in substitution reactions, while alcohols may be used in a wide variety of reactions. Compounds such as this may be used as intermediates in building lipids for use in lipid nanoparticles.

Lipid 10 is an ionizable lipid which may be used to develop lipid nanoparticles in drug discovery. The structure features a methylpiperazine head, a central tertiary amine, and two identical polyunsaturated C20 tails. The prescence of three amines in this structures allows it to carry up to three positive charges depending on pH. Ionizable lipids such as this may be applied in the development of lipid nanoparticles for drug delivery.

BP Lipid 317 is an amino lipid featuring a dimethylamine headgroup connected to two oleic esters and a hydroxy group which may be used for further derivatization. Ionizable lipids such as this may be applied in the development of lipid nanoparticles for drug delivery. Reagent grade, for research purpose. Please contact us for GMP-grade inquiries.

BP Lipid 318 is a lipid analog comprised of three unsaturated fatty acid tails and an ionizable dimethylamino butanoate head group. This lipid may be used in the generation of lipid nanoparticles (LNPs) for mRNA delivery. Reagent grade, for research purpose. Please contact us for GMP-grade inquiries.