Lipids

1,2-Dioleoyl-sn-glycero-3-PEG8-Azide functions as a click-chemistry lipid with two oleic acid unsaturated fatty acid tails and an azide head group to perform click reactions with DBCO, BCN, alkyne. The PEG units enhance the overall water solubility of the compound.

1,2-Dioleoyl-sn-glycero-3-PEG12-Azide is described by an azide click-chemistry handle at the head and two oleic acid unsaturated fatty acid tails.

DSPE-Rhodamine B is a fluorescent lipid containing a DSPE phospholipid and a Rhodamine B fluorophore.

cKK-E15 serves as an ionizable lipid. It plays a crucial role in creating lipid nanoparticles (LNPs).

SM-102 N-oxide is an impurity that may be present in commercial formulations of SM-102.

Lipid AX4 serves as an ionizable lipid in lipid nanoparticles (LNPs) for in vivo mRNA delivery.

C12-113 functions as an ionizable cationic lipidoid. Researchers have harnessed its properties by combining it with other lipids to formulate lipid nanoparticles (LNPs). These LNPs serve as a vehicle for delivering mRNA encoding the spike glycoprotein of the severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) in mice.

C12-SPM is a lipidoid characterized by a branched-chain structure containing polyamine moieties. Researchers have employed it in conjunction with other lipids to create lipid nanoparticles (LNPs). These LNPs serve as carriers for delivering small interfering RNA (siRNA) that specifically targets the host protein kinase C-related kinase 2 (PRK2).

RM 133-3 is an ionizable lipid that researchers have employed in the creation of lipid nanoparticles (LNPs).