Lipids

BP Lipid 418 is an ionizable lipid featuring a unique azetidine head group and two unsaturated fatty acid tails. Additional features include three biodegradable ester linkages. This compound may be used in the formulation of lipid nanoparticles (LNP's) for delivery applications. Reagent grade, for research purpose. Please contact us for GMP-grade inquiries.

BCN-PEG2-Glu-Gly-Cit-PAB-OH serves as a special cleavable tripeptide linker that offers exceptional stability in the bloodstream, resisting degradation and human neutrophil protease cleavage, while enabling discrete, traceless intracellular release of payloads. The BCN group reacts with azide-tagged compounds or biomolecules. The PEG units impart water-solubility of the molecule and help in fine-tuning DMPK properties. Reagent grade, for research purpose. Please contact us for GMP-grade inquiries.

(2R,3R)-1,4-bis(6-bromohexylate)butane-2,3-diol

Cy3-DSPE is an amphiphilic polyPEG which allows encapsulation of nutrients or therpeutics via formation of lipid bilayer for targeted drug delivery system, sucha as liposomes as carrier of mRNA vaccine. The Cy3 fluorophore is commonly used in applications such as immunolabeling, nucleic acid labeling, fluorescence microscopy, and flow cytometry. The dye has an absorption wavelength that peaks around 548-552 nm, and an emission maximum around 562-570 nm. Reagent grade, for research purpose. Reagent grade, for research purpose. Please contact us for GMP-grade inquiries.

t-Boc-N-Amido-PEG3-Ms represents a PEG linker with a mesyl group, which is a good leaving group for nucleophilic reactions, and a Boc group, which can be deprotected under mildly acidic conditions to liberate the amine. The PEG units increase the hydrophilicity of the molecule. Reagent grade, for research purpose. Please contact us for GMP-grade inquiries.

DSPE-PEG-PA, MW 2,000 functions as a PEG polymer containing DSPE and a carboxylic acid end group. The hydrophobic properties of the DSPE allow for the encapsulation and congregation of other hydrophobic drugs. The hydrophilic PEG increases the water solubility of the overall compound allowing for the delivery of the drug. The carboxylic group can undergo sequential amide coupling reaction with amine-bearing biomolecules in the presence of EDC or HATU. Reagent grade, for research purpose. Please contact us for GMP-grade inquiries.

DSPE-Cy7 formic acid salt is a fluorophore attached lipid with formic acid salt form. Cy7 is a near infrared fluorescent dye. This reagent can be utilized to produce Cyanine7-labeled biomolecules for subsequent use in various in vivo research, and drug design related experiments. The hydrophobic properties of the DSPE allow for the encapsulation and congregation of other hydrophobic drugs. Reagent grade, for research purpose. Please contact us for GMP-grade inquiries.

m-PEG-NH2 HCl salt, MW 10,000 serves as a linear methoxy PEGylation polymer with a primary amine, which can easily react with an NHS ester to form a stable amide bond. The 10k PEG polymer greatly improves the water-solubility of the molecule. Reagent grade, for research purpose. Please contact us for GMP-grade inquiries.

Cholesterol esters (CEs) can modulate membrane fluidity and bilayer thickness upon interacting with triacylglycerols (TAGs) and phospholipids (PLs). Formulation of CEs into lipid nanoparticles may serve to tune the physical properties of lipid nanoparticles for delivery applications. Reagent grade, for research purpose. Please contact us for GMP-grade inquiries.