Lipids

NHS ester-PEG4-MMAF serves as a payload conjugate containing NHS ester which is highly reactive towards amines, a PEG4 spacer for enhanced water-solubility and aiding in the optimization of DMPK properties, and MMAF which is a synthetic antineoplastic agent that may be employed as a cytotoxic payload in the creation of antibody-drug conjugates (ADCs). Reagent grade, for research purposes. Please contact us for GMP-grade inquiries.

D-Glu-OtBu-PEG8-azide

DMPE-PEG-amine, MW 2,000, TFA salt is a phospholipid used in biological membranes, featuring a DMPE-PEGylated structure with a methyl-terminated PEG chain. The PEG component is amphiphilic, aiding in the formation of stable micelles in aqueous solutions. This phospholipid is ideal for preparing nanoparticles or liposomes for targeted drug delivery. The amine moiety can be further derivatized for conjugation. Reagent grade, for research purpose. Please contact us for GMP-grade inquiries.

BP Lipid 420 is a symmetric polar lipid featuring a two unsaturated oleic acid tails and a hydroxyl group. This compound may be used for bioconjugation and surface modification applications, or as a useful synthetic scaffold for novel lipids. Reagent grade, for research purpose. Please contact us for GMP-grade inquiries.

BP Lipid 421 is a symmetric polar lipid featuring a two unsaturated oleic acid tails and a BOC-protected amino group. This compound may be used for bioconjugation and surface modification applications, or as a useful synthetic scaffold for novel lipids. Reagent grade, for research purpose. Please contact us for GMP-grade inquiries.

BP Lipid 423 is a symmetric polar lipid featuring a two unsaturated oleic acid tails and an azido group for click chemistry. This compound features biodegradeable ester and amide linkages may be used for bioconjugation and surface modification applications, or as a useful synthetic scaffold for novel lipids. Reagent grade, for research purpose. Please contact us for GMP-grade inquiries.

BP Lipid 424 is a symmetric polar lipid featuring a two unsaturated oleic acid tails and a DBCO group for click chemistry. This compound may be used for bioconjugation and surface modification applications, or as a useful synthetic scaffold for novel lipids. Reagent grade, for research purpose. Please contact us for GMP-grade inquiries.

Val-Cit-PAB-MMAE is a derivatized linker-payload that can be used in the creation of antibody-drug conjugates (ADCs). It contains a cathepsin-cleavable Val-Ala dipeptide and an MMAE payload, which is a synthetic antineoplastic agent that can be attached to a monoclonal antibody (MAB) which directs it toward cancer cells. The azide moiety can react with alkyne, BCN, and DBCO via Click Chemistry to yield a stable triazole linkage. The PEG spacer enhances the water-solubility of the compound and may aid in optimizing DMPK properties. Reagent grade, for research purpose. Please contact us for GMP-grade inquiries.

An ionizable lipid featuring a two biodegredable ester linkages to unsaturated oleic acid tails. Additional features include a core hydroxyl group to promote hydrogen-bonding with neighboring lipids. This compound may be used in the formulation of lipid nanoparticles (LNP's) for delivery applications. Reagent grade, for research purpose.