Lipids

Phosphatidylinositol 5-phosphate diC8 (ammonium salt) is a synthetic purified dioctanoyl PI(5)P.Phosphoinositides (PIPns) are minor components of cellular membranes but are integral signaling molecules for cellular communication. Phosphatidylinositol 5-phosphate (PI(5)P) is a rare lipid found in the nucleus that can bind the PHD finger of the nuclear adapter protein ING2. PI(5)P is phosphorylated to PI(4 5)P2 by Type II PIP kinases.Featured in Publications:1) Ikonomov O. C. D. Sbrissa et al. (2002). "Functional dissection of lipid and protein kinase signals of PIKfyve reveals the role of PtdIns 3 5-P2 production for endomembrane integrity." J Biol Chem 277(11): 9206-11.2) Hinchliffe K. A. M. L. Giudici et al. (2002). "Type IIalpha phosphatidylinositol phosphate kinase associates with the plasma membrane via interaction with type I isoforms." Biochem J 363(Pt 3): 563-70.3) Sbrissa D. O. C. Ikonomov et al. (2002). "Phosphatidylinositol 5-phosphate biosynthesis is linked to PIKf

Phosphatidylinositol 5-phosphate diC16 (PI(5)P diC16) is a synthetic purified dipalmitoyl PI(5)P.Phosphoinositides (PIPns) are minor components of cellular membranes but are integral signaling molecules for cellular communication. Phosphatidylinositol 5-phosphate (PI(5)P) is a rare lipid found in the nucleus that can bind the PHD finger of the nuclear adapter protein ING2. PI(5)P is phosphorylated to PI(4 5)P2 by Type II PIP kinases.Alternate Names: D-myo-Phosphatidylinositol 5-phosphate Dipalmitoyl Phosphatidylinositol 5-phosphate PtdIns(5)P C16 PI(5)P C16 or PI5PBulk discounts available please email echelon@echelon-inc.com for information.Publications Powered by Bioz See more details on Bioz1) Barylko B. S. H. Gerber et al. (2001). "A Novel Family of Phosphatidylinositol 4-Kinases Conserved from Yeast to Humans." J Biol Chem 276(11): 7705-7708.2) Sbrissa D. O. C. Ikonomov et al. (2004). "Role for a Novel Signaling Intermediate Phosphatidylinositol 5-Phosphate in Insulin

PtdIns(4 5)P2 a-fluorophosphonate diC16 (ms-PtdIns(4 5)P2 diC16) is a synthetic PI(4 5)P2 analog in which the phosphodiester bond has been rendered metabolically stable via the α-fluorophosphonate. Powered by Bioz See more details on Bioz

Flow PIPs: Multiplex Lipid Beads are microparticles with attached lipids that can be used to determine and study lipid-protein interactions.Each pack of Flow PIPs: Multiplex Lipid Beads contain two mixes of assay particles. Each bead mix Mix A & Mix B contains six separately coated beads that vary in both the coating lipid and the fluorescence intensity of the bead allowing the user to determine if their protein of interest binds with one or more of the bound lipids in a multiplex cytometric format.Storage: 2-8 °C. Product is temperature and light sensitive. Do not freeze.Publications Powered by Bioz See more details on Bioz1. Zhang J Dubey P Padarti A Zhang A Patel R Patel V et al. Novel functions of CCM1 delimit the relationship of PTB/PH domains. Biochimica et Biophysica Acta (BBA) - Proteins and Proteomics. 2017;1865(10):1274-86.DocumentsTechnical Data Sheet

PtdIns(4 5)P2 a-fluorovinylphosphate diC8 is a water soluble synthetic PI(4 5)P2 analog in which the phosphodiester bond has been rendered metabolically stable via the α-fluorovinylphosphonate. P-FV4508 restores the TRPM4 ion channel current at similar concentrations as diC8-PI(4 5)P2.Featured in PublicationsJ. Am. Chem. Soc. 2006 Powered by Bioz See more details on Bioz

The PIP PACK is a bundle of lipid-protein interaction tests controls and a wash case.The pack contains: 5 PIP Strips and 2 Membrane Lipid Strips to identify binding 2 PIP Arrays to quantify binding affinity 2 vials of PI(4 5)P2 specific binding protein (G-4501) for use as positive controls 1 wash caseSphingo Strips (S-6000) and Sphingo Arrays (S-6001) can be substituted in the PIP Pack. Powered by Bioz See more details on Bioz

Inositol phosphates are important signaling molecules involved in numerous cellular functions. Inositol 1 3-bisphosphate (Ins(1 3)P2) is an intermediate in the inositol phosphate pathway being produced by dephosphorylation of Ins (1 3 4)P3 by type II inositol 1 3 4 trisphosphate 4-phosphatase.

Inositol phosphates are important signaling molecules involved in numerous cellular functions. Inositol 1 4-bisphosphate (Ins(1 4)P2) is an intermediate in the inositol phosphate pathway. It is produced by dephosphorylation of Ins(1 4 5)P3 by a 5-phosphatase thus terminating IP3 signaling. Ins(1 4)P2 is also a substrate for inositol 1-phosphatase. Powered by Bioz See more details on Bioz

Inositol phosphates are important signaling molecules involved in numerous cellular functions. Inositol 1 5-bisphosphate (Ins(1 5)P2) is not an intermediate in the inositol phosphate pathway but corresponds to the PtdIns(5)P headgroup. Powered by Bioz See more details on Bioz