Lipids

**This product is being discontinued but stock is currently available.  Please call to place order: 801-588-0455**Membrane permeant inositol polyphosphates are employed in cell signaling experiments to introduce exogenous inositol polyphosphates across cell membranes. Some examples of applications are listed below. See the following page for an example protocol.1) M. Vajanaphanich et al. “Long-term uncoupling of chloride secretion from intracellular calcium levels by Ins(3 4 5 6)P4” Nature 1994 971 711-714.2) M.T. Rudolf et al. ”A membrane-permeant bioactivatable derivative of Ins(1 3 4)P3 and its effect on Cl(-)-secretion from T84 cells” Bioorg. Med. Chem.Lett. 1998 8 1857-1860.3) X. Yang et al. “Inositol 1 3 4-trisphosphate acts in vivo as a specific regulator of cellular signaling by inositol 3 4 5 6-tetrakisphosphate.” J. Biol. Chem. 1999 274 18973-18980.

Methyl glucoside sesquistearate (CAS 68936-95-8) is a non-ionic carbohydrate based surfactant and emulsifier used in membrane research and in cosmetics and dermatological preparations. This glycolipid has also been explored as a solubilizing agent for controlled drug delivery.

Ascorbyl stearate is a fatty acid ester formed from ascorbic acid and stearic acid. In addition to its use as a source of vitamin C it is used as an antioxidant food additive in margarine. The USDA limits its use to 0.02% individually or in conjunction with other antioxidants.

Sorbitan monostearate also known as Span 60TM is an ester of sorbitan (a sorbitol derivative) and stearic acid and is sometimes referred to as a synthetic wax. It is primarily used as an emulsifier to keep water and oils mixed. Sorbitan monostearate is a non-ionic surfactant with emulsifying dispersing and wetting properties.

Decyl rhamnoside surfactants are suitable for use in cosmetics including in anti-aging creams soaps and other skin or facial treatments. Furthermore these materials may have anti-bacterial anti-zoosporic and anti-fungal properties. Agriculture uses are known as well as bioremediation and enhanced oil recovery projects. Decyl rhamnoside (like many of its natural rhamnose-based derivatives) is a good foaming and wetting agent with the ability to increase the aqueous solubility of hydrophobic compounds making them excellent solubilizing and emulsifying agents for diverse applications.Produced in collaboration with GlycoSurf LLC (glycosurf.com.)

Sphingosine is formed through ceramidase catalyzed hydrolysis of ceramide. It is a potent inhibitor of protein kinase C (IC50 = 1-3 μM). Sphingosine is phosphorylated by sphingosine kinase to the bioactive lipid sphingosine 1-phosphate. Powered by Bioz See more details on Bioz

Sphingosine-biotin is an alkyl-labeled sphingosine synthesized with the natural erythro stereochemistry that maintains its natural properties.Sphingosine is formed through ceramidase catalyzed hydrolysis of ceramide. It is a potent inhibitor of protein kinase C (IC50 = 1-3 μM). Sphingosine is phosphorylated by sphingosine kinase to the bioactive lipid sphingosine 1-phosphate. Labeled sphingosines can be phosphorylated by sphingosine kinases (1 & 2) and can be used in high throughput screening applications. In addition they induce a Nieman Pick type C1 disease cellular phenoype in RAW macrophages in the same manner as exogenously added sphingosine.

Sphingosine-fluorescein is an alkyl-labeled sphingosine synthesized with the natural erythro stereochemistry that maintains its natural properties.Sphingosine is formed through ceramidase catalyzed hydrolysis of ceramide. It is a potent inhibitor of protein kinase C (IC50 = 1-3 μM). Sphingosine is phosphorylated by sphingosine kinase to the bioactive lipid sphingosine 1-phosphate. Labeled sphingosines can be phosphorylated by sphingosine kinases (1 & 2) and can be used in high throughput screening applications. In addition they induce a Nieman Pick type C1 disease cellular phenoype in RAW macrophages in the same manner as exogenously added sphingosine. Powered by Bioz See more details on Bioz

Sphingosine-tetramethylrhodamine is an alkyl-labeled sphingosine synthesized with the natural erythro stereochemistry that maintains its natural properties.Sphingosine is formed through ceramidase catalyzed hydrolysis of ceramide. It is a potent inhibitor of protein kinase C (IC50 = 1-3 μM). Sphingosine is phosphorylated by sphingosine kinase to the bioactive lipid sphingosine 1-phosphate. Labeled sphingosines can be phosphorylated by sphingosine kinases (1 & 2) and can be used in high throughput screening applications. In addition they induce a Nieman Pick type C1 disease cellular phenoype in RAW macrophages in the same manner as exogenously added sphingosine.