Lipids

PolyPIPosomes are polymerized liposome-like nanoparticles which show markedly increased stability (up to 6 months) vs. conventional liposomes. A biotin tag is incorporated for easy detection of PIPn-binding proteins with streptavidin reagents or coated surfaces.PI(3 4 5)P3 PolyPIPosomes are provided as a 1mM total lipid solution containing 5% PI(3 4 5)P3. Each order of 250 μL or 1 mL of PolyPIPosomes includes 100 μL of Control PolyPIPosomes. Powered by Bioz See more details on Bioz

PolyPIPosomes are polymerized liposome-like nanoparticles which show markedly increased stability (up to 6 months) vs. conventional liposomes. A biotin tag is incorporated for easy detection of PIPn-binding proteins with streptavidin reagents or coated surfaces.PI(4 5)P2 PolyPIPosomes are provided as a 1mM total lipid solution containing 5% PI(4 5)P2. Each order of 250 μL or 1 mL of PolyPIPosomes includes 100 μL of Control PolyPIPosomes. Powered by Bioz See more details on Bioz

D-Lin-MC3-DMA (MC3) is a potent synthetic ionizable lipid. Its full name is (6Z,9Z,28Z,31Z)-Heptatriaconta-6,9,28,31-tetraen-19-yl 4-(dimethylamino)butanoate. D-Lin-MC3-DMA has been used in combination with other lipids in the formation of lipid nanoparticles (LNPs) for the delivery of siRNA, mRNA, DNA. The pKa is 6.44. Reagent grade, for research use only.

Rhodamine B labeled lipopolysaccharide (LPS) is one of red fluorescent LPS conjugates from Nanocs. Nanocs offers several fluorescent conjugates of lipopolysaccharides from Escherichia coli and Salmonella minnesota. LPS, also called endotoxins, are complex macromolecules present on the outer cell walls of gram-negative bacteria. Our fluoresent LPS allow researchers to follow binding, transport and cell internalization processes of LPS.

DSPE-PEG4-DBCO is a PEG linker containing DSPE and DBCO moieties. The DSPE-PEGs have been FDA approved for medical applications. The hydrophobic properties of the DSPE allow for the encapsulation and congregation of other hydrophobic drugs. The hydrophilic PEG linker increases the water solubility of the overall compound allowing for the delivery of the drug. The DBCO group can be used for copper-free Click Chemistry reactions. Reagent grade, for research purpose. Please contact us for GMP-grade inquiries.

Phosphatidylcholine (PC) is generally the most abundant lipid in animal cell membranes providing structural framework. PC is more common in the outer leaflet where it functions as part of the permeability barrier. PC is also the primary substrate of Phospholipase D enzymes which produce the signaling lipids-phosphatidic acid and lysophosphatidic acid. This analog is deuterated on the choline headgroup.

ALC-0315 is a synthetic amino lipid. It is a colorless oil. ALC-0315 is one of four components that form lipid nanoparticles (LNPs) in mRNA-based COVID-19 vaccines. It encapsulates and protects the fragile mRNA which is the active ingredient in these drugs. IUPAC name: [(4-Hydroxybutyl)azanediyl]di(hexane-6,1-diyl) bis(2-hexyldecanoate). The pKa is 6.09. Reagent grade, for research use only.

SM-102 is a synthetic ionizable lipid which is used in combination with other lipids to form lipid nanoparticles (LNP) for drug delivery. These are used for the delivery of mRNA-based COVID-19 vaccines. The pKa is 6.68. Reagent grade, for research use only.

Ionizable lipids in combination with other lipids make up the lipid nanoparticles which are used to deliver RNA-based therapeutics. cKK-E12 has been used to deliver siRNA in mice rats and primates (ED50 = 0.002 0.01 & 0.3 mg/kg respectively). It shows low toxicity and is selective for liver parenchymal cells over liver heart lung and kidney endothelial cells. This product is for research use only and not for human use.