Lipids

Phosphatidylcholine (PC) is generally the most abundant lipid in animal cell membranes providing structural framework. PC is more common in the outer leaflet where it functions as part of the permeability barrier. PC is also the primary substrate of Phospholipase D enzymes which produce the signaling lipids-phosphatidic acid and lysophosphatidic acid. This analog is deuterated on the choline headgroup.

Phosphatidylcholine (PC) is generally the most abundant lipid in animal cell membranes providing structural framework. PC is more common in the outer leaflet where it functions as part of the permeability barrier. PC is also the primary substrate of Phospholipase D enzymes which produce the signaling lipids-phosphatidic acid and lysophosphatidic acid. This analog is deuterated on the choline headgroup.

LysoPC is generated through hydrolysis of the sn-2 acyl chain of PC by phospholipase A2. It is a major component of oxidized low-density lipoprotein and is believed to have an important role in inflammatory diseases and atherosclerosis. LysoPC is the substrate for Autotaxin/LysoPLD generating lysophosphatidic acid which has an important role in cell motility. This analog is deuterated on the choline headgroup.

LysoPC is generated through hydrolysis of the sn-2 acyl chain of PC by phospholipase A2. It is a major component of oxidized low-density lipoprotein and is believed to have an important role in inflammatory diseases and atherosclerosis. LysoPC is the substrate for Autotaxin/LysoPLD generating lysophosphatidic acid which has an important role in cell motility. This analog is deuterated on the choline headgroup.

LysoPC is generated through hydrolysis of the sn-2 acyl chain of PC by phospholipase A2. It is a major component of oxidized low-density lipoprotein and is believed to have an important role in inflammatory diseases and atherosclerosis. LysoPC is the substrate for Autotaxin/LysoPLD generating lysophosphatidic acid which has an important role in cell motility. This analog is deuterated on the choline headgroup.

LysoPC is generated through hydrolysis of the sn-2 acyl chain of PC by phospholipase A2. It is a major component of oxidized low-density lipoprotein and is believed to have an important role in inflammatory diseases and atherosclerosis. LysoPC is the substrate for Autotaxin/LysoPLD generating lysophosphatidic acid which has an important role in cell motility. This analog is deuterated on the choline headgroup.May contain up to 10-15% of the 2-acyl isomer.

Ionizable lipids in combination with other lipids make up the lipid nanoparticles (LNPs) which are used to deliver RNA-based therapeutics. LNPs incorporating Lipid 5 (from Sabnis et al.) demonstrated potent delivery of mRNA in primates but also were rapidly cleared from the body resulting in low toxicity. Lipid 5 was better at I.V. delivery to the liver while the closely related SM-102 (cat# N-1102) was optimized for intramuscular administration. This is a reagent grade product for research use only.

DLin-MC3-DMA is an ionizable lipid used in combination with other lipids for encapsulation of RNA and DNA into lipid nanoparticles (LNPs). Administration of DLin-MC3-DMA based LNPs have delivered siRNA and reduced Factor VII levels in mice. Delivery of BCR-ABL siRNA reduced leukemic burden in a mouse model of chronic myeloid leukemia (CML).This product is for research use only and not for human use. Additional information can be found here.

Isoprenoids and isoprenols are key metabolic intermediates for biosynthesis of steroids including cholesterol and hormones that regulate human reproduction or fertility and posttranslational modifications of proteins in signal transduction pathways for cell division and regulation of vesicular trafficking. Farnesol is an acyclic sesquiterpene alcohol and the 2E 6E-isomer being the most common in nature. 2Z 6E-Farnesol is a metabolite in the sesquiterpenoid and triterpenoid biosynthesis formed by farnesol 2-isomerase from 2E 6E-farnesol.