Lipids

C12-200 is a branched-chain ionizable lipidoid with five hydroxyl groups. It has been used in combination with other lipids in the formation of lipid nanoparticles (LNPs) for the delivery of mRNA, siRNA, or self-amplifying RNA (saRNA). The hydroxyl groups enables further derivatization or replacement with other reactive functional groups. Reagent grade, for research use only.

DMG-PEG 2000, also called 1,2-dimyristoyl-rac-glycero-3-methoxypolyethylene glycol-2000, is used for liposome preparation. DMG-PEG 2000 has become known for lipid nanoparticle (LNP) preparation for siRNA (small interfering RNA) delivery in the COVID-19 vaccine development. Reagent grade, for research purpose.

DOTMA is one of the first cationic lipid used for gene transfection. It is an effective transfection agent in vitro and in vivo. DOTMA carries a positive charge on the surface of liposomes which condenses anionic nucleic acids and promotes efficient interactions between the cell membrane and the liposome. Reagent grade, for research use only.

DOPE, also known as 1,2-Dioleoyl-sn-glycero-3-PE or 1,2-DOPE, is a synthetic analog of naturally-occurring PE containing 18:1 fatty acids at the sn-1 and sn-2 positions. 1,2-DOPE can be used as an emulsifier to facilitate DNA-liposome complex transport across membranes. It is used in combination with cationic phospholipids to increase efficiency during DNA transfection studies as a non-viral method of gene delivery. Reagent grade, for research use only.

DSPE-PEG-OH, MW 2,000 is a polyPEG containing a DSPE phospholipid and a hydroxyl group. The DSPE-PEGs have been FDA approved for medical applications. The hydrophobic properties of the DSPE allow for the encapsulation and congregation of other hydrophobic drugs. The hydrophilic polyPEG chain increases the water solubility of the overall compound allowing for the delivery of the drug. The hydroxyl group allows for further derivatization of the compound. Reagent grade, for research purpose.

DLin-KC2-DMA is an ionizable lipid for siRNA delivery. It was formulated and characterized in SNALP and demonstrated to have in vivo activity at siRNA doses as low as 0.01 mg/kg in rodents and 0.1 mg/kg in nonhuman primates. The pKa is 6.2. Reagent grade, for research use only.

BP Lipid 106 is an amino ionizable lipid with ester bonds located at C7 relative to nitrogen. The ethanolamine head can effectively enhance mRNA encapsulation while ester bonds improve tissue clearance. The primary lipid tail contains 11 carbons. The ionizable lipid can be used for mRNA delivery due to its excellent physiochemical properties. Reagent grade, for research purpose. Please contact us for GMP-grade inquiries.

LP01 is a biodegradable ionizable lipid which can reduce liver bioaccumulation significantly compared to levels observed in ionizable lipids such as MC3. This lipid can form nanoparticles that can encapsulate and deliver siRNA, mRNA, DNA or small molecules into cells. The pKa is 6.1. Reagent grade, for research use only.

BP Lipid 216 is an amine lipid which has both ester bonds located adjacent to C7 relative to the nitogen amine. The head contains ethanolamine which can efficiently encapsulate mRNA. The lipid can be used to prepare mRNA nanocarriers with good balance of delivery efficiency and pharmakokinetics as well as rapid lipid clearance profile. Reagent grade, for research purpose. Please contact us for GMP-grade inquiries.